“Objective: To investigate the outcome of cochlear implantation in children with postmeningitic deafness and to compare the outcomes in ossified and nonossified cochleas.
Study Design: A retrospective case note review of children with postmeningitic deafness requiring cochlear implantation.
Setting: Manchester Auditory Implant Centre-a tertiary referral center.
Patients: Children younger than 16 years with postmeningitic deafness.
Cochlear implantation to aid auditory habilitation.
Main Outcome Measure: Outcomes were measured using Categories of Auditory Performance Score and the Manchester Speech and Language Development Scale.
Results: Fifty-two children underwent C188-9 in vivo cochlear implantation. Patients were allocated to 2 groups-Group 1 with nonossified
cochleas and Group 2 with cochlear ossification. Group 1 comprised 25 children, of whom, 22 had Categories of Auditory Performance Score of 5 or higher. Nineteen of www.selleckchem.com/products/SRT1720.html them were able to use simple phrases of 3 words or more on the Manchester Speech and Language Development Scale. Group 2 comprised 27 children. Fourteen had partial ossification with complete standard electrode insertion in all instances. Of the 13 children with gross ossification, 3 had scala vestibuli insertion, 7 had split electrode insertion and 3 had partial electrode insertion. In this group, 20 children had Categories of Auditory Performance Score of 5 or higher. Nineteen children were able to use simple phrases of 3 words or more on Manchester Speech and Language Development Scale.
Conclusion: Children with postmeningitic deafness benefit significantly from cochlear implantation. However, the audio-logic outcomes are difficult to predict, especially in the presence of cochlear ossification. Acquisition of speech and language in these children after cochlear implantation is possible even in the presence of gross RG7321 cochlear ossification.”
“Bartonella henselae, a small fastidious Gram-negative bacillus, is the causative agent of cat-scratch disease (CSD). Because of difficulty in isolating the organism, there has been no
report on its antibiotic susceptibility in Japan. We determined the minimal inhibitory concentrations (MICs) of eight antimicrobial agents against 32 isolates of B. henselae (31 from cats and one from a human in Japan) by the Etest method. MICs of all 32 isolates were < 0.016 mu g/ml for minocycline and ranged from a parts per thousand currency sign0.016 to 0.064 mu g/ml for erythromycin, clarithromycin, azithromycin, ceftriaxone, and amoxicillin. MICs ranges of ciprofloxacin and gentamicin were from 0.064 to 0.25 mu g/ml and from 0.5 to 3 mu g/ml, respectively. All isolated strains showed high susceptibility to minocycline and macrolides antibiotics, which are currently used in the primary treatment of CSD in Japan. Although in vitro result of B.