Os autores declaram não haver conflito de interesses. “
“In populations with high incidence of tuberculosis (TB), there have been an increased number of TB cases reported in patients treated with tumor necrosis factor
antagonists (anti-TNF).1 In fact, the relative risk (RR) of developing TB is 1.6–25.2 times higher in Rheumatoid Arthritis (RA) patients under anti-TNF therapy than in RA patients treated with conventional immunosuppressive therapy, depending on the clinical setting and the anti-TNF used.1, 2, 3, 4, 5, 6 and 7 Active TB in the context of Docetaxel research buy anti-TNF therapy usually results from the reactivation of a latent infection, shortly after the beginning of the treatment.5 and 8 TB often presents an atypical behavior, which may pose difficulties to the diagnosis.9 In countries with high incidence of TB, cases caused by new infection are also particularly frequent. TNF is fundamental for the immunological defence against Mycobacterium tuberculosis, especially in the formation and maintenance of granulomas. Animal models confirmed that it is possible to reactivate TB after administering anti-TNF antibodies. 10 Besides anti-TNFs,
17-AAG datasheet other biological agents were approved for immune mediated inflammatory disease’s treatment. Data about the risk of developing TB infection in patients treated with these other agents are scarce. Even though this risk might be lower for some of the biological agents that do not interfere with TNF until more data is available this group assumed that this position paper should be applied to all biological treatments. Preventive chemotherapy can significantly reduce the incidence of active TB in individuals with latent infection, identified by positive tuberculin skin test (TST) or interferon-γ release assay (IGRA).11
The currently available evidence about the best management to prevent TB in patients receiving biological therapy is limited. In this position paper on the screening and prevention of TB in patients treated with biological therapy, delegates from Urease the Tuberculosis Committee (TC) of the Portuguese Pulmonology Society (SPP), the Rheumatoid Arthritis Study Group (GEAR) of the Portuguese Society of Rheumatology (SPR), the Portuguese Society of Dermatology and Venereology (SPDV) and the Portuguese Society of Gastroenterology (SPG), have revised and updated recommendations that had been previously developed by the GEAR – SPR and by the TC – SPP, first published in 200612 and latter updated in 2008.13 The main objective of this position paper is to contribute for the reduction of the number of cases of reactivated TB and new TB infections in patients with immune mediated inflammatory diseases who are candidates for treatment with biological therapy in Portugal.