There was no difference in the prevalence of hypertension (56 %),

There was no difference in the prevalence of hypertension (56 %), diabetes (35 %) or stroke/transient ischemic attack (16 %). The one-year mortality rate was 23 %, while 31 %

of patients were rehospitalized; the combined end point was 51 %. Enrollment in an HF clinic was independently associated with reduced risk of total mortality (hazard ratio [HR] 0.69 [95 % CI 0.51 to 0.90], P=0.008; number needed to treat for one year to prevent the occurrence of one event [NNT]=16), all-cause hospital readmission (HR 0.27 [95 % CI 0.21 to 0.36], P < 0.0001; NNT=4), and combined mortality or hospital readmission (HR 0.73 [95 % CI 0.60 to 0.89], P < 0.0015; NNT=5).DISCUSSION:

HF clinics are associated with reductions in rehospitalization and mortality in an unselected HF population, independent of whether they are Apoptosis Compound Library cell line academic- or community-based. Such clinics should check details be made widely available to the HF population.”
“The discovery of specific gene mutations, termed driver mutations, in different tumors has brought personalized medicine into the focus of cancer treatment. Targeted treatment agents generally are administered orally and have a tolerable adverse event profile; they have become widely used in both inpatient and outpatient settings. The approval of the selective BRAF inhibitor

vemurafenib (Zelboraf (R)) as first-line therapy of metastatic melanoma in Europe in February 2012 as well as the increasing use of MEK inhibitors within clinical trials confronts dermatologists and oncologists with a new spectrum of side effects. Knowledge of these possible adverse events and their management will be crucial

for optimized patient care. This article offers an overview of the most important adverse events of currently employed dermato-oncologic therapeutic agents.”
“Pacemaker generator replacement is a simple procedure that is mostly done on outpatient basis. Electrocautery is almost universally used for bleeding control and tissue dissection. Ventricular fibrillation (VF) caused by electrocautery in these procedures is a very uncommon occurrence and an underappreciated possibility with modern day devices. We report a case of monomorphic ventricular tachycardia induced by electrocautery in a patient with normal left ventricular ejection fraction during elective pacemaker generator change. ( PACE 2009; 32: 957-958)”

Studies have suggested that patients who have undergone the Fontan procedure experience lower functional health status and diminished exercise capacity compared with other children.OBJECTIVES:

To compare the functional health status of Fontan patients with and without siblings, assess whether there are any differences between Fontan patients and their siblings, and determine associated factors.

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