Able 4 shows the effects and the Smad signaling critical starting point for a degradation product. For alachlor ESA, some differences were noted, but no statistically significant effect was considered undesirable and without a thorough analysis of individual data, including normal and clinical chemistry or in a workshop of the drinking water or 91 in a study with 90-day feeding. The h HIGHEST dose in the study 90 days, the food is reasonable and the basis of the NOAEL RfD, because there is less than the h HIGHEST dose used in the study of drinking water. For alachlor OXA, the h HIGHEST dose as the NOAEL was appropriate because only minimal changes Ver Of K Rpergewichts were observed in the study, 90 days without food statistically significant difference between control and treated animals. The critical effects of acetochlor ESA were a decrease in weight gain, decreased feed intake and reduced food use in the study noted 90 days food, middose with the NOAEL. For acetochlor OXA, have an average dose NOAEL for weight gain and reduced food use in the study 90 days food have been identified. Endpoints with statistically significant Ver Changes or trends were also used for the modeling using the U.S. EPA benchmark dose software 1.4. However, the H Not the length of BMD values, is the most reliable Ssiger than the NOAEL and LOAEL are identified cause, were mainly due to the lack of a clear dose-response relationship. In some cases F In which an acceptable fit of the data was Histone deacetylase performed, the reference dose is not considered a good starting point because the maximum effect of the h Chsten dose was observed, was significantly lower than the response reference typically 10% decline in K rpergewichts compared to contr them. There was a concern because the big e extrapolation of data adds uncertainty to the Sch Estimates and projections BMDL had a big there is potential for suitable not a BMDL above the critical threshold for the effects, the calculation of Co in modeling . The outputs Length k in BMD can see Under available. 3.3. Step 3: Areas of uncertainty, which have by deriving a reference dose of EPO United States proposed five different uncertainty factors to address issues of variability t and address uncertainty in the calculation of the reference and cans deliberations of the committee on each of these five areas are down specified. Because human health without data or comparative data on toxicokinetics or toxicodynamics between rats and humans is available, was a factor of 10 from the judges to be appropriate for the UFA, for all the degradation products. 3.3.2. Variability t seen within the panel assessment that insufficient information was available to have a value of 10 for UFH and information, it does not, which would be the development of an adjustment factor to chemical specific it Change variability Tons of people. The factor of 10 for human variability T was found sufficient because the show limited uptake and metabolism of degradation products, that the variability of t k in the toxicokinetics nnten Be lower than for other chemicals. This finding was consistent with the fact that a factor has been applied from 1 FQPA able to two related herbicides, indicating that the toxicity t database is complete. For acetochlor, was a safety factor for FQPA only short periods, lack of dev created.