stretch induced significant ERK1 / 2 relative Glu receptor to static culture BMP4 phosphorylation. Cell suppression tron We BMP4 induces adipogenesis by MSC was deteriorated when the cells were stretched with a pharmacological blocker of ERK. Combined, elongation of the cells suppresses the induction of BMP4 MSC adipogenesis potentially via upregulation ERK but not through the down-regulation of Smad or p38. And negatively regulate adipogenesis of MSC common pathways, activated by the bypass expansion signal L Soluble factor induction. The field of mechanobiology and mechanotransduction in it, focuses Haupts Chlich on the r Of the various mechanical Kr Forces in the activation of intracellular Ren cascades and the fate of cells. One of the most studied signal transduction pathways are the mitogen-activated protein kinases, the environmental signals into biochemical reactions and are known to be essential in cell growth, differentiation and stress response. Since the induction l soluble factor, could the mechanical pulses which have an influence on the cells on one or more of the three MAPKs: p38, p42/44 and c Jun N-terminal kinase. We recently reported the R Important for the activation of p42/44 plays both stimulates chondrogenesis and osteogenesis of mesenchymal stem cells by TGF B3. Lund et al have shown that when the signals tats microenvironment in a scaffold of collagen type 1, the inhibition of ERK1 / 2 subjected Chlich to an increase Hten reaction osteogenic cells resulted in inhibition and chondrogenic differentiation simultaneously. The authors suggested that the three-dimensional arrangement of which was related to the upregulation of the expression of osteogenic and chondrogenic cells pleased t any biochemical or stimulation of collagen type I substrate led to the scaffold used. In Similar way, the activation of ERK1 / 2 reported by other researchers, at least partially non-critical to be hydrostatic pressure-induced osteogenesis of bone marrow mesenchymal stem cells. However, other reports showed both biochemical and mechanical stimuli combined opposite results, the only evidence presented that the use of mechanical / physical. Kim et al showed that the expression is regulated encapsulated by osteogenic 5 alpha dht marker osteocalcin and osteopontin to in MSCs in poly stands and a cyclic hydrostatic pressure in the presence of osteogenic media in comparison to those of the unloaded constructions in the media itself This study has shown that the bone formation was in the presence of U0126, a potent and selective inhibitor of the p42/44 MAPK, compressed and suppresses non-compressed cell constructs. The intricacies of the Ph Were months owing by studies showing no additive effect when both mechanical stimulation and exogenous cytokine supplementation in osteogenesis and chondrogenesis of stem cells are combined highlighted. Based on the only mechanical stimulation, we performed experiments in our laboratory the potential of dynamic compressive loading on chondrogenic differentiation of various stem cell populations have shown induce. Dynamic Marbofloxacin compression leads to a significant Erh Increase the expression of the two TGF-b receptors 1 and II and the m Possible involvement of p42/44 MAPK by the rapid up-regulation.