Research frontiers Endoscopes have now been designed to improve mucosal visualization, with a wide angle of view, filter-aided techniques that can enhance characterization of mucosal morphology and surface architecture, and high-resolution/high-definition MEK162 ARRY-438162 imaging that can improve endoscopic recognition of mucosal lesions. In this study, the authors demonstrated that the routine use of HD+ plus i-Scan recognized more mucosal lesions without the need to prolong the withdrawal time to allow closer inspection. Innovations and breakthroughs Recent studies have analyzed the capacity of high-definition imaging to improve the lesion detection rate during colonoscopy with conflicting results. The value of high-definition colonoscopy in clinical practice is still debated.

In this study, the authors showed that the routine addition of i-Scan to HD+ imaging during the entire withdrawal phase of the colonoscopy significantly increased the diagnostic yield for detection of mucosal lesions of the colon, particularly small and nonprotruding ones, without affecting the withdrawal time, and could probably enable less-skilled endoscopists to achieve performances comparable to those of experienced ones in detecting mucosal lesions. Applications This study may encourage the utilization of advanced imaging technologies to reduce polyp miss rate and improve colonoscopy performance in the prevention of colorectal cancer. Terminology The i-Scan technology is a digital contrast method employing a light filter that uses different software algorithms with real-time image mapping embedded in the Pentax EPKi processor.

i-Scan enhances mucosal imaging by activating three distinct functions: one for surface enhancement (SE), the second for contrast enhancement (CE), and the third for tone enhancement (TE), allowing a better recognition and characterization of the mucosal lesions during colonoscopy. SE mode enhances the structure through recognition of the edges, compared to normal images, and allows easier recognition of minute glandular structures which makes it simpler to identify changes on the basis of structural differences. CE mode enhances minute irregularities Entinostat and depressed areas of the mucosal surface with a slight bluish-white stain. In TE mode, the RGB components of an ordinary endoscope image are broken down into their parts, and each one is then converted independently along the tone curve, followed by resynthesis of the three components to yield a reconstructed image. Peer review The authors examined the role of HD+ i-Scan vs white-light colonoscopy on polyp detection rates. The research is a significant addition to the literature on the use of contrast technology in improving the quality of colonoscopy in detecting polyps.