In patients with

dilated cardiomyopathy, global Crenolanib datasheet ventricular remodeling occurs with resultant displacement of both PMs. In contrast, in patients with functional/ischemic MR due to inferior infarction, localized ventricular remodeling is more common with resultant posteromedial PM displacement.8) Real-time 3D echocardiography has proven that in patients with functional MR due to dilated cardiomyopathy, symmetrical PM displacement lead to progressive cordal tethering and leaflet tenting, resulting in Inhibitors,research,lifescience,medical predominantly central MR as a result of decreased leaflet coaptation.9-11) On the other hand, in patients with ischemic MR, left ventricular remodeling caused by abnormal wall motion results in uneven papillary displacement and asymmetric tethering associated with eccentric MR.9),12-14) Three dimensional TEE allows us to directly visualize the decreased leaflet coaptation and the differences of the coaptation

depth in each segment.15) Mitral annulus shows a nonplanar saddle-shaped configuration in healthy individual.16) There are two peaks Inhibitors,research,lifescience,medical at the aortic insertion and posterior left ventricular wall and two low troughs closest to the apex located medially and laterally (Fig. 1).1),2),17) The saddle shape is most remarkable during mid-systole.18) The annulus acquires Inhibitors,research,lifescience,medical a more flattened shape at early-systole and end-diastole.19) The curvature contributes to the mechanism that mitral leaflets have an effective coaptation and to reduction the stresses imposed by left ventricular pressure during systole.20) Inhibitors,research,lifescience,medical Kwan et al.21) demonstrated

the enlargement and less nonplanarity mainly in the anteroposterior direction during systole in patients with global left ventricular systolic dysfunction. These geometric changes were proportional to the global left ventricular systolic function. Our group Inhibitors,research,lifescience,medical has demonstrated dilatation and flattening of the mitral annulus in patients with ischemic MR22) and more deformation in anterior infarction compared to posterior infarction (Fig. 2 and ​and33).22),23) Fig. 2 Mitral annulus configuration. Three dimensional echocardiography allowed us to visualize the dilatation and flattening of the mitral annulus Montelukast Sodium in patients with ischemic mitral regurgitation and more deformation in anterior infarction compared to posterior … Fig. 3 Visualizing the annular flattening and leaflet tenting. The reconstructed three-dimensional (3D) images by Real View allow us to understand the annular flattening or mitral leaflet tenting in patients with functional mitral regurgitation (MR) and it also … SURGICAL THERAPEUTIC STRATEGY FOR FUNCTIONAL MR As previously mentioned, functional MR is a predictor of mortality in patient with left ventricular dysfunction. The survival of patients with functional MR, even with mild MR is significantly worse than in patients with the same degree of organic MR.