The saponins could be responsible for the observed antidiabetic, lipid and cholesterol lowering activities. 11 From the results obtained correlation among antiradical and α-amylase inhibitory potential was established. It could be concluded that the

aqueous and ethyl acetate fractions possess significant antiradical property and inhibitory potential on α-amylase. All authors have none to declare. The authors are thankful to Prof. Ashok Kumar, Vice-Chancellor, C.S.J.M. University, Kanpur for providing the necessary facilities at University Institute of Pharmacy. “
“Hyperlipidemia is the major cause of atherosclerosis and atherosclerosis-associated conditions, such as coronary heart disease (CHD), ischemic cerebro-vascular disease, and peripheral vascular disease. Although the incidence of these atherosclerosis-related events selleck chemicals has declined in the United States, these conditions still account for the majority of morbidity and mortality among middle-aged and older adults.

The incidence and absolute number of annual events will likely increase over the next decades because of the epidemic of obesity and the aging of the U.S. population. Therefore, there is a great need for methods for treatment of lipid disorders, especially those which predispose a patient to cardiovascular problems such as myocardial infarction, angina conditions, stroke, coronary artery R428 nmr disease, etc.1 and 2 Fluvastatin sodium (FVS) is the first fully synthetic HMG-CoA reductase inhibitor approved for clinical lipid lowering therapy. FVS is subjected to extensive first pass metabolism in the liver and the plasma half-life of the drug is approximately 3 h with 40%–60% bioavailability. The physicochemical characteristics of drug like low molecular mass (411.46 g/mol) and log Po/w (3.24) favors molding of it in transdermal drug delivery system.3 Through literature review, it was revealed that so far no one

has attempted transdermal delivery or novel drug delivery of fluvastatin sodium. In the present research work, transdermal matrix patch was fabricated with use of FDA approved commercial acrylate-co-polymer based pressure sensitive adhesives. old Effect of different permeation enhancers, Eudragit polymer and matrix fillers were investigated.4 Fluvastatin sodium was a gift sample from Biocon Limited, India. Durotak 87-9301 (DT 9301) & Durotak 87-900A (DT 900A) were obtained from Henkel Ltd. (Salisbury NC, USA). Transcutol P (TC) was obtained from Colorcon Asia, Mumbai, India. Isopropyl myristate (IPM) and Oleyl alcohol (OLA) were purchased from S D Fine-Chem Limited, Mumbai. Oleic acid (OA), Propylene glycol (PG), Colloidal silicone dioxide (CSD) and Eudragit RL 100 (E RL 100) were obtained from Loba Chem pvt ltd, Mumbai, India.