However, even when the spoken

words are masked in this way, we can usually still hear the spoken words and comprehend the content of speech as if it were not masked. The auditory system has the capability to restore the interrupted parts of the TSA HDAC molecular weight spoken words, and can help to perceptually restore the masked portions of the spoken words to meaningful speech, using cues such as expectations, linguistic knowledge, syntactic, semantic, and lexical constraints, and context in noisy environments; this phenomenon is known as phonemic restoration (Warren, 1970, Warren et al., 1972, Warren et al., 1997, Warren and Bashford, 1981, Verschuure and Brocaar, 1983, Sivonen et al., 2006 and Davis and Johnsrude, 2007). Some degree of age-related impairment of speech comprehension, particularly

in noisy environments, is common among older adults. In this population, in addition to a simple loss of acuity due to loss of cochlear hair cells, higher-level auditory processing deficits may make spoken words unclear or garbled even when properly amplified or corrected by hearing aids (Jerger et al., 1989). Disability of phonemic restoration, which is considered to be caused by hearing loss (Başkent, 2010 and Başkent

et al., 2010), could be as one of the primary reasons for impaired speech comprehension in noisy environments (Plomp and Mimpen, 1979, GSK J4 chemical structure Duquesnoy, 1983, Dubno et al., 1984 Teicoplanin and Schneider et al., 2000). Clarifying the neural mechanisms of phonemic restoration thus seems useful to develop treatment methods for those who suffer from impaired speech comprehension, particularly in noisy environments. Although functional magnetic resonance imaging (fMRI) studies (Petkov et al., 2007a, Riecke et al., 2007 and Shahin et al., 2009) have been performed to clarify the neural mechanisms of phonemic restoration, those studies focused solely on the perceived continuity against interrupted noise stimuli. The roles of speech comprehension on phonemic restoration should not be underestimated, and to further clarify the neural mechanisms underlying phonemic restoration, studies focusing on speech comprehension against interrupted noise stimuli would be useful. Neural mechanisms related to the restoration of speech comprehension should thus be clarified. We focused on the neural mechanisms related to the restoration of speech comprehension in healthy young participants in our present study.