CrossRef 25. Burke LM, Wood C, Pyne DB, Telford RD, Saunders PU: Effect of carbohydrate intake on half-marathon performance of well-trained runners. Int J Sport Nutr Exerc Metab 2005, 15:573–589.PubMed Competing interests NVP-BEZ235 research buy The authors declare that they have no competing interests. Authors’ contributions BT participated in the design of the study, recruitment of subjects, data collection, data analysis and drafted the

manuscript. SC assisted in the design of the study, recruitment of subjects, data collection and data analysis. KH assisted in the recruitment of subjects, data collection and data analysis. LA participated in the design of the study and manuscript preparation. BD participated in the design of the study and manuscript preparation. GC participated in the design of the study, data collection, data analysis, statistical analysis and helped draft the manuscript. All authors read and approved the final manuscript.”
“Background The Polycomb group (PcG) genes were first identified in Drosophila as a class of regulators responsible for maintaining homeotic gene expression throughout cell division [1], PcG genes are conserved from Drosophila www.selleckchem.com/screening/autophagy-signaling-compound-library.html to mammals, and the expression levels of mammalian PcG genes differ between different tissues and cell types [2], PcG genes

act as epigenetic silencers during embryo morphogenesis with a central role in the nervous system, heart, and skeleton development [3–7].In addition, PcG members have been involved in the regulation of such adult processes as the cell cycle, X-inactivation, and hematopoiesis [8–14]. PcG expression is deregulated in some types of human cancer [15].Moreover, several PcG genes may regulate the self-renewal of specific stem cell types, suggesting a link between the maintenance of cell homeostasis

and carcinogenesis [16, 17]. Bmi-1 is one of the key PcG proteins. It was initially identified as an oncogene that cooperated with c-Myc in the generation of mouse pre-B-cell lymphomas. It is also considered the first functional mammalian PcG protooncogene to be recognized, and it has been implicated in axial patterning, hematopoiesis, cell cycle regulation, and senescence [18–21]. Human Bmi-1 gene is located at the short arm of chromosome 10p13 Prostatic acid phosphatase [22], The region is involved in chromosomal translocations in leukemia and is amplified in non-Hodgkin’s lymphoma as well as in solid tumors [23]. Bmi-1 induces S-phase entry by inhibiting Rb function via repression of the INK4a/ARF locus [24–26]. Moreover, overexpression of Bmi-1 in mammary epithelial cells may activate telomerase and lead to immortalization [27]. Overexpression of Bmi-1 has been found in several human malignancies including breast cancer, colorectal cancer, nasopharyngeal carcinoma, melanoma, gastric cancer, and bladder cancer [28–33]. Overexpression of Bmi-1 often correlates with poorer prognosis and treatment failure [30, 32–34].