Consistent with previous research, participants typically reported learn more high levels of purpose in life. Scores were also observed to vary over the 12-month duration, with, on average, an increase in purpose in life at Time 2. However, tests of longitudinal invariance were inconclusive.
Future research is needed to further examine the content validity of the LET, and its factorial invariance over longer measurement intervals, and across different populations including non-residential/aged care settings.”
“Objective: To investigate whether macrophages in the synovial lining can be selectively eliminated
by local administration of an improved boron-10 (B-10) containing liposome formulation combined with neutron irradiation (boron neutron capture synovectomy [BNCS]).
Methods: Disodium dodecahydrododecaborate ((Na2B12H12)-B-10) was encapsulated into unilamellar liposomes beta-catenin tumor (B-10-liposomes). B-10-liposomes were injected into the mouse knee joint. Amounts of B-10 in synovial tissue were measured over time using inductively coupled plasma-optical emission spectrometry (ICP-OES). Arthritis was induced in knee joints of mice. Joint inflammation and cartilage destruction was measured using histology.
Results: When a 10 mu l B-10-liposome solution (containing 40 mu g B-10) was injected into the murine knee joint, high concentrations of
B-10 were measured in macrophages in the synovial lining (At 24 h 306 +/- 226 mu g . g(-1) macrophages). Completing the BNCS by neutron irradiation of the legs 24 h after B-10-liposome injection showed a clear selective depletion of macrophages in synovial lining of
the knee joints. An estimated total physical dose of 13 +/- 9 Gy was given to the macrophages. When arthritis was induced in the macrophage-depleted joints, swelling of the knee was significantly lower as compared to the controls (53% and 79% lower at days 1 and 3, respectively). Histology confirmed the influx of inflammatory cells was strongly decreased and severe cartilage destruction was almost completely prevented.
Conclusion: BNCS using an improved B-10-containing liposome formulation can cause selective depletion of macrophages in the synovial lining of murine knee joints. As a result of this proof-of principle, future applications are recommended.”
“BACKGROUND:
Wait times Citarinostat molecular weight for cardiac surgery are well established but may not reflect the total wait time patients experience.METHODS:
The Maritime Heart Center (Halifax, Nova Scotia) cardiac surgery database was used to identify all consecutive patients who underwent elective coronary artery bypass graft surgery between 2002 and 2005 from a single urgency queue. The provincial physician billing database provided a timeline record of dates, physician visits, and diagnoses or procedures performed for each patient. This information was used to assess total and component wait times leading to cardiac surgery.