3 (the best cutoff by receiver operating characteristic

curve: sensitivity 67.5%, specificity 64.5%; area under the curve 0.659) on multivariate analysis, we obtained similar results (OR 2.791, 95% CI 1.261-6.175, P = 0.01). By contrast, VAI at the threshold of 1, which is considered normal,18 was not significantly associated with steatosis ≥30% on multivariate analysis (OR 1.681, 95% CI 0.691-4.098, P = 0.25). Figure 2 shows the distribution of VAI scores in terms of steatosis. Ixazomib chemical structure The univariate and multivariate comparisons of variables between patients with and without moderate to severe necroinflammatory activity are reported in Table 4. Multivariate logistic regression analysis revealed that the following features were independently linked to moderate to severe necroinflammatory activity: older age (OR 1.030, 95% CI 1.002-1.059, P = 0.03), higher VAI score (OR 1.618, 95% CI Roscovitine price 1.001-2.617, P = 0.04), and fibrosis (OR 2.608, 95% CI 1.565-4.345, P < 0.001). When replacing VAI with triglycerides, the latter remained significantly associated with moderate to severe necroiflammatory activity (OR 1.010, 95% CI 1.001-1.020, P = 0.03). In addition, when replacing VAI as the continuous variable with VAI as the categorical variable at the threshold of 1, VAI score was not significantly associated with moderate to severe necroinflammatory

activity on multivariate analysis (OR 1.713, 95% CI 0.855-3.431, P = 0.12). By contrast, VAI at the above-mentioned threshold of 1.3 remained independently associated with moderate to severe necroinflammatory activity on multivariate analysis (OR 2.619, 95% CI 1.199-5.722, P = 0.01). Figure 3 shows the distribution of VAI scores in terms of necroinflammatory activity. Older age, higher WC, high ALT and platelet (PLT) levels, steatosis, and necroinflammatory activity were associated with severe Thymidine kinase fibrosis (P < 0.10). VAI score as continuous variable, and as categorical variable at the thresholds of 1 and 1.3, was not associated with severe fibrosis. Multivariate logistic regression analysis showed that the following features were

independently linked to severe fibrosis: high PLT levels (OR 1.003, 95% CI 1.001-1.005, P = 0.02), steatosis (OR 1.026, 95% CI 1.007-1.045, P = 0.008), and necroinflammatory activity (OR 2.106, 95% CI 1.180-3.761, P = 0.01). Of 162 patients who underwent and completed the antiviral treatment program, SVR was achieved in 77 (47.5%). Older age, high WC, high triglycerides, high blood glucose, high HOMA, high IR, diabetes, high VAI score, and steatosis were associated with lack of SVR at a threshold of P < 0.10 (Table 5). Logistic regression analysis revealed that older age (OR 0.970, 95% CI 0.944-0.997, P = 0.02) and steatosis (OR 0.969, 95% CI 0.945-0.993, P = 0.01) were the only independent negative predictors of SVR.