62 Migration An increased risk of CHIR-258 supplier schizophrenia has been demonstrated among Surinamese migrants in the Netherlands,71 African refugees in Sweden,72 Greek migrants to Belgium,73 and Scandinavian migrants to Denmark.74 A systematic review confirmed a high incidence of schizophrenia among many migrants and ethnic minority groups, and especially black

migrants to European countries.4 The AESOP study confirmed that all ethnic minority groups in England are at increased Inhibitors,research,lifescience,medical risk for schizophrenia, but that African-Caribbeans and black Africans show an especially high risk with a ninefold and sixfold increase in the incidence respectively compared with white Britons.75 Many previous studies in the UK have reported similar findings.76-82 This excess is not a consequence of misdiagnosis.83-85 Furthermore, African-Caribbeans do not show an increased Inhibitors,research,lifescience,medical risk of psychosis in the West Indies,86-88 indicating that genes alone cannot explain the findings. Hutchinson et al showed that among the siblings of Caribbean patients in the Inhibitors,research,lifescience,medical UK, the risk was much

lower in those sibs mostly living in the West Indies compared with those mostly living in the UK.89 This implies some environmental factor operating in the UK but not in the West Indies. Boydell et al demonstrated that as the proportion of non-white ethnic minorities in a given neighbourhood in London decreases, the incidence of schizophrenia in this minority increases.6,90 The finding was subsequently replicated in the Netherlands, Inhibitors,research,lifescience,medical and suggests an ameliorating effect of social support or of decreased exposure to adversities such as racial discrimination, in areas with relatively high proportions

of ethnic minorities.91 Childhood adversity Parental loss or separation It has been noted that permanent separation from, or death of, one or both parents was associated with a more Inhibitors,research,lifescience,medical than threefold increased risk of schizophrenia (but not bipolar disorder).92 Similarly, it was observed in the AESOP study that psychotic cases were three times more likely than controls through to have experienced a longterm separation from one or both parents and to have had a parent die before the age of 16. 93 Child abuse Of course, parental separation and loss are associated with a range of adverse early experiences, including family conflict, socioeconomic disadvantage, and neglect and abuse.94 Evidence is emerging that childhood physical abuse may increase risk of later psychosis, but whether childhood sexual abuse is particularly culpable is contentious.95 Bullying The association between bullying and severe mental health problems, including self-harm, violent behavior, and psychotic symptoms has attracted recent attention.