A pathologic evaluation of target biopsies showed 11 patients with neoplasia, which was detected by both techniques in 4 patients, whereas only 4 cases were detected using NBI endoscopy alone and ATM/ATR targets 3 cases using white light endoscopy. Van den Broek and colleagues38 also reported that 11 of 16 (69%) neoplastic lesions were detected by white

light, whereas NBI endoscopy detected 13 of 16 (81%) cases (nonsignificant differences). Efthymiou and colleagues42 reported that when using chromoendoscopy, 131 lesions (92%) were detected as compared with 102 lesions (70%) with NBI (P<.001); the median number of lesions detected per patient was 3 with chromoendoscopy and 1.5 with NBI (P = .002). NBI magnification, however, was not used in these clinical studies. The authors, thus, have continued to study the use of magnifying endoscopy

with NBI in their unit in Hiroshima (Fig. 1, Fig. 2 and Fig. 3). The authors think that it is possible that the reported results in the literature were negative because of the difficulty to accurately discriminate between active inflammation and neoplasia. The authors also studied other potential advantages of the use of NBI magnification. Bisschops and colleagues40 reported that the withdrawal time for NBI was significantly shorter than that of CE, although NBI endoscopy and CE showed equivalent dysplasia detection rates. Pellisé and colleagues37 reported that NBI endoscopy had a significantly inferior false-positive biopsy www.selleckchem.com/products/LBH-589.html rate and a similar true-positive rate compared with CE. It has been reported that the magnified observation of UC using NBI is useful to discriminate between dysplastic/neoplastic and non-neoplastic lesions and to guide for the necessity of performing a target biopsy.

East and colleagues found that dysplasias were seen as darker capillary vascular patterns. Matsumoto and colleagues36 reported that the tortuous pattern of capillaries determined by NBI endoscopy might be a clue for the identification of dysplasia BCKDHA during surveillance colonoscopy for patients with UC. The authors have previously reported the clinical usefulness of NBI magnification for the qualitative diagnosis of sporadic colorectal lesions by the combined evaluation of both surface pattern and microvessel features.55 The surface pattern is thought to be more useful for endoscopic findings because inflammation causes the structure of microvessel features to become disordered. AFI is a novel technique that uses a short-wavelength light to excite endogenous tissue fluorophores that emit fluorescent light of longer wavelength. AFI highlights neoplastic tissue without the administration of exogenous fluorophores as described earlier in UC.43, 44 and 45 AFI images of UC lesions can be classified into 4 categories: green, green with purple spots, purple with green spots, and purple. The strength of the purple staining in AFI images of UC lesions is related to the histologic severity.