Although previous studies have demonstrated that various ID rabies vaccine schedules provide long lasting immunity,10,11 the persistence of antibodies after a TRID2 schedule warrants further investigation. The antibody response to subsequent vaccine boosters after the TRID2 schedule also needs to be assessed, but it is reassuring that other studies have shown good response to boosters a year or more after standard and abbreviated rabies ID vaccination www.selleckchem.com/products/dabrafenib-gsk2118436.html schedules.9,10,14,15 The immunogenicity of TRID2 should also be compared to other abbreviated schedules using ID rabies vaccines.10,14,16 The use of the ELISA technique rather than the WHO recommended gold standard RFFIT method should also be taken

into account when interpreting the results of this study.1,12 The TRID2 schedule should be considered an option for pre-exposure rabies vaccination in clinics with staff who are experienced at administering ID vaccines. Further research is required to confirm the findings in this case series, assess the

variation in response between different age groups and gender, and determine the optimal timing of vaccine doses and serology. If such additional work supports our findings, it may become appropriate to consider revisions to the current vaccination guidelines to include a modified ID pre-exposure Obeticholic Acid price rabies vaccination schedule. We would like to thank the staff at Dr Deb—The Travel Doctor, Brisbane, Australia for collecting the data, and Justine Jackson (RN) for managing and collating the data. This study was not subsidized, funded or associated with Janus kinase (JAK) the vaccine manufacturers in any way. D. J. M. and C. L. L. are doctors at privately owned, independent travel medicine clinics, and provide rabies vaccines to travelers. The other authors state they have no conflicts of interest to declare. “
“A 54-year-old woman presented with 2 weeks of fever after a trip to the Northeastern United States. Except for an erythematous

skin lesion on her right shoulder, no physical abnormality was detected. We diagnosed concomitant borreliosis and babesiosis. Both infections were possibly acquired by one bite from Ixodes scapularis. A 54-year-old woman presented in July 2009 with a 2-week history of chills and fever up to 40°C. Because of her job as event manager, she had visited Egypt, Costa Rica, and South Africa over the past years. In February and March 2009, she had traveled to Indonesia (Bali, Sulawesi, and Papua) taking atovaquone–proguanil as malaria chemoprophylaxis. On a recent trip to the United States in June, she had visited Boston, the Niagara Falls area, and Cape Cod where she went hiking with a friend. We saw a moderately ill, febrile woman, neither anemic nor jaundiced. Except for an erythematous skin lesion of 5 cm diameter on her right shoulder, no physical abnormalities were detected.