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“Background: Even though specific agents for the treatment of patients with pulmonary hypertension (PH) are available, in PH patients, physical capacity and quality of life (QoL) are often restricted and survival is reduced. Objectives: This study prospectively investigated the long-term effects of respiratory and exercise training in patients with severe chronic PH regarding safety, time to clinical worsening and survival. selleck chemicals Methods: Fifty-eight consecutive patients with severe

PH on stable disease-targeted medication received exercise and respiratory training in hospital for 3 weeks and continued at home. They were prospectively followed for 24 8 12 months. Primary endpoints were time to clinical worsening and survival. Adverse events and changes in the 6-min walking test, QoL, WHO functional class and gas exchange were secondary endpoints and were evaluated at baseline and at weeks 3 and 15. Results: All patients tolerated the exercise training well without severe adverse events. In week 15, 6-min walking test results were significantly improved compared to baseline (by 84 +/- 49 m, p

< 0.001), as well as QoL scores, WHO functional class (from Doramapimod research buy 2.9 +/- 0.5 to 2.6 +/- 0.6, p < 0.01), peak oxygen consumption (from 12.5 +/- 3.0 to 14.6 +/- 3.9 ml/min/kg, p < 0.001), heart rate at rest (from 75 +/- 12 to 61 +/- 18 beats/min, p < 0.001) and maximal workload (from 65 +/- 21 to 80 +/- 25 W, p < 0.001). Survival at 1 and 2 years was 100 and 95%, respectively. Fifteen events occurred during the follow-up. Conclusion: This study indicates that exercise

and respiratory training as add-on to medical treatment may improve Smad inhibitor exercise capacity and QoL, and that they have a good long-term safety in the described setting. Copyright (C) 2011 S. Karger AG, Basel”
“Non-ablative bipolar and monopolar radiofrequency devices have been shown to be effective for the treatment of facial wrinkles. Recently, novel fractionated microneedle radiofrequency (FMRF) devices have been introduced. The aim of this study was to evaluate the clinical effectiveness and safety of FMRF for the treatment of periorbital wrinkles. Eleven women, aged 3459years, with periorbital wrinkles underwent three sessions of FMRF at 3-week intervals with a follow-up period of 3months after treatment. Clinical improvement was evaluated using the Fitzpatrick Wrinkle Classification System (FWCS) and subjective satisfaction on a visual analog scale (VAS). The FWCS scores demonstrated significant improvement in periorbital wrinkles after treatment (P<0.001). A satisfaction VAS score of more than 5, indicating high satisfaction, was obtained from 10 of 11 patients (91%) 3months after treatment, and the mean satisfaction VAS score (n=11) was 6.7.