E blood cells w re Pancytopenia in patients with oxaliplatin-induced positive and the positive reactions were treated only in the presence of the drug. As a mechanism for AIHA in this case, drug-induced formation of IgG antibody Rpern against red Blutk Rperchen of oxaliplatin loan St Bendamustine Ribomustin was suspected. Because IgG and complement C3b and C3d complex can activate strongly detected on erythrocytes, the complement system, k nnte The antique car Body inducing acute H Thermolysis severeintravascular and what to LCI. We believe that treatment of plasma exchange and drugs with improved corticostéro Of AIHA by lowering the concentration of antibodies Rpern in turn reduces the causes of Tubul Re necrosis. It should be noted, mild thrombocytopenia was observed in the present case before the occurrence of AIHA, but deteriorated with the development of AIHA. Worsening thrombocytopenia by autoimmune mechanisms that are induced as described above, but directly k bone marrow and other causes In this case can not be excluded, because none of the bone marrow examinations were performed. Why exactly H thermolysis Occurred at this time remains uncertain. The intensive use of platinum-containing chemotherapy w During the last decade has led to a significant increase in the incidence of hypersensitivity reactions. Markman et al. reported a patient who was H thermolysis after first-line treatment with 6 G developed lengths of carboplatin, which have caused the sensitization k nnten. Re treatment with the same drug can immunological stimulation is Pemetrexed Antimetabolites inhibitor required to make a H Thermolysis produce associated AKI have provided. The patient in this case was in Similar way, sensitized by a long-term treatment with oxaliplatin, leading to H Thermolysis. H Thermolysis-induced AKI is often oliguric, but Chow et al. a case of non-oliguric AKI induced H thermolysis due to the HNP.
The difference between oliguric and oliguric AKI is not generally reported to be due to the Ausma the injury. No, no, oliguric renal and fast recovery of AKI in patients with this may be limited to damage to Tubul Ren epithelial pleased that t serious injuries have been associated. In summary, we have the first case of thermolysis of AKI related H Due to oxaliplatin in Japan. Medical conditions were successfully treated with steroids Of, plasma exchange and the H Hemodialysis. Oxaliplatin should be used as a drug to pl relooking life threatening H Thermolysis of antique Body, which can be induced by drugs and following AKI, although oxaliplatin is often administered without significant side effects are noted. Platinum complexes, widely used in the treatment of a variety of human tumors used, but their clinical efficacy by intrinsic and acquired often nkt Descr. In recent years, many conducted in vitro studies, the mechanisms of platinum resistance aufkl Ren. Among Imiquimod other things, reduced the accumulation of platinum compounds seems to be a Middle finger to play in the development of resistance. Ren the mechanism of resistance aufzukl, It is n TIG, examine the accumulation of platinum Determining cellular mechanisms. It is widely accepted that the influx of cellular Ren-platinum complexes by passive diffusion and facilitated transport mechanisms and is mediated active. A contribution of copper Transpo.