Biol Chem 2006, 387:1175–1187.PubMedCrossRef 8. Fritz WA, Lin TM, Safe S, Moore RW, Peterson RE: The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol 2009, 77:1151–1160.PubMedCrossRef 9. Peng TL, Chen J, Mao W, Liu X, Tao Y, Chen LZ, Chen MH: Potential therapeutic
significance of increased expression of aryl hydrocarbon receptor in human gastric cancer. World J Gastroenterol 2009, 15:1719–1729.PubMedCrossRef 10. Barouki R, Coumoul X, Fernandez-Salguero PM: The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett 2007, 581:3608–3615.PubMedCrossRef 11. Cole P, Trichopoulos D, Pastides H, Starr T, Mandel JS: Dioxin and cancer: a critical review. Regul Toxicol Pharmacol 2003, selleck chemicals 38:378–388.PubMedCrossRef 12. Bradfield CA, Bjeldanes LF: Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. J Toxicol Environ Health 1987, 21:311–323.PubMedCrossRef 13. Chen I, Safe S, Bjeldanes L: Indole-3-carbinol and diindolylmethane as aryl hydrocarbon selleck screening library (Ah) receptor agonists and antagonists in T47D human Erismodegib nmr breast cancer
cells. Biochem Pharmacol 1996, 51:1069–1076.PubMedCrossRef 14. Kim EJ, Park SY, Shin HK, Kwon DY, Surh YJ, Park JH: Activation of caspase-8 contributes to 3,3′-Diindolylmethane-induced apoptosis in colon cancer cells. J Nutr 2007, 137:31–36.PubMed 15. Koliopanos A, Kleeff J, Xiao Y, Safe S, Zimmermann A,
Büchler MW, Friess H: Increased aryl hydrocarbon receptor expression offers a potential therapeutic target in pancreatic cancer. Oncogene 2002, 21:6059–6070.PubMedCrossRef 16. Ciolino HP, Daschner PJ, Yeh GC: Resveratrol inhibits transcription of CYP1A1 in vitro by during preventing activation of the aryl hydrocarbon receptor. Cancer Res 1998, 58:5707–5712.PubMed 17. Revel A, Raanani H, Younglai E, Xu J, Rogers I, Han R, Savouret JF, Casper RF: Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene. J Appl Toxicol 2003, 23:255–261.PubMedCrossRef 18. Mandal PK: Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. J Comp Physiol B 2005, 175:221–230.PubMedCrossRef 19. Safe S, McDougal A: Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). Int J Oncol 2002, 20:1123–1128.PubMed 20. Sugihara K, Okayama T, Kitamura S, Yamashita K, Yasuda M, Miyairi S, Minobe Y, Ohta S: Comparative study of aryl hydrocarbon receptor ligand activities of six chemicals in vitro and in vivo. Arch Toxicol 2008, 82:5–11.PubMedCrossRef 21. Chen I, McDougal A, Wang F, Safe S: Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.