Cell Mol Life Sci 2005, 62:3014–3038.PubMedCrossRef 11. Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E: Crystal structure of Stattic mw IIGP1: a paradigm for interferon-inducible p47 resistance GTPases. Mol Cell 2004, 15:727–739.PubMedCrossRef 12. Takai Y, Sasaki T, Matozaki T: Small GTP-binding proteins. Physiol Rev 2001, 81:153–208.PubMed 13. Hippenstiel S, Schmeck B, N’Guessan PD, Seybold
J, Krüll M, Preissner K, Eichel-Streiber CV, Suttorp N: Rho protein AZD1390 molecular weight inactivation induced apoptosis of cultured human endothelial cells. Am J Physiol Lung Cell Mol Physiol 2002, 283:L830–838.PubMed 14. da Silva CV, da Silva EA, Cruz MC, Chavrier P, Mortara RA: ARF6, PI3-kinase and host cell actin cytoskeleton in Toxoplasma gondii cell invasion. Biochem Biophys Res Commun 2009, 378:656–661.PubMedCrossRef 15. Howard JC, Hunn JP, Steinfeldt T: The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii . Curr Opin Microbiol 2011, 14:414–421.PubMedCrossRef 16. Papic N, Hunn JP, Pawlowski N, Zerrahn J, Howard JC: Inactive and active states of the interferon-inducible resistance GTPase, Irga6, In Vivo. J Biol Chem 2008, 283:32143–32151.PubMedCrossRef 17. Hall A: Rho GTPases and the actin cytoskeleton. Science 1998, 279:509–514.PubMedCrossRef 18. Maddala R, Reddy VN, Epstein DL, Rao V: Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization
in human lens epithelial cells. Mol Vis 2003, 17:329–36. 19. Taylor GA: IRG proteins: key mediators of interferon-regulated host resistance to intracellular Selleck BLZ945 pathogens. Cell Microbiol 2007, 9:1099–1107.PubMedCrossRef 20. Hunn JP, Koenen-Waisman S, Papic N, Schroeder N, Pawlowski N, Lange R, Kaiser
F, Zerrahn J, Martens S, Howard JC: Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii . EMBO J 2008, 27:2495–2509.PubMedCrossRef 21. Zhao YO, Khaminets A, Hunn JP, Howard JC: Disruption of the Toxoplasma gondii parasitophorous vacuole RANTES by IFN gamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog 2009, 5:e1000288.PubMedCrossRef 22. Zhao Y, Ferguson DJ, Wilson DC, Howard JC, Sibley LD, Yap GS: Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol 2009, 182:3775–3781.PubMedCrossRef 23. Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD: Phosphorylation of immunity-related GTPases by a Toxoplasma gondii -secreted kinase promotes macrophage survival and virulence. Cell Host Microbe 2010, 8:484–495.PubMedCrossRef 24. Yin J, Lu J, Yu FS: Role of small GTPase Rho in regulating corneal epithelial wound healing. Invest Ophthalmol Vis Sci 2008, 49:900–909.PubMedCrossRef 25.