Cognitive change in normal aging Age-related changes in cognition among the healthy are well documented. Several psychometric measures of attention, memory, and reasoning abilities, as well as those emphasizing speed, display particularly robust age-related declines. Less pronounced declines in measures of knowledge, such as vocabulary, are observed with age.162-164 Although much of this information is based on cross-sectional studies, longitudinal Inhibitors,research,lifescience,medical sequences from the Seattle Longitudinal Study, among others, confirm the existence of age-related decline

on several measures of cognitive performance.7,165 -168 “Data on rates of aging … suggest that a rapid rise to peak performance in the third and fourth decades of life is followed by a ”continuous decline’ which is slight, over the fifth and sixth decades and thereafter rapidly accelerates“ (Rabbitt, 1990).169 While investigators may disagree as to the ages at which Inhibitors,research,lifescience,medical decline in cognitive function occurs, there is a consensus in the aging literature that cognition does not decline uniformly across the life span. One of the clearest, findings to emerge from the field

of cognitive aging is that Inhibitors,research,lifescience,medical older adults are unable to recall as much as younger adults from long-term memory. 162,170,171 Memory difficulties worsen with advancing age and are a major aging complaint.172-174 Many older adults find their memory and cognitive impairments debilitating on a daily basis and find that they interfere with many of their daily activities. It was the recognition of age-associated cognitive decline that, appeared to go beyond that typically associated with normal aging that led to the classification Inhibitors,research,lifescience,medical of such problems as AACD and MCI. Defining normal

vs MCI vs pathological aging Over the past 20 years there have been several proposals regarding how best, to characterize the spectrum of memory function in nondemented older adults. Ferris Inhibitors,research,lifescience,medical and Klugcr175 have reviewed in detail the following proposed characterizations: mild cognitive impairment (MCI), age-associated memory impairment (AAMI), and age-related cognitive decline (ARCD). While initial descriptions of MCI suggested that some individuals likely decline on a variety of cognitive domains, more recently, MCI has come to refer more TCL specifically to presence of memory’ impairment greater than expected for an individual’s age, with general, cognitive function preserved and no other neurological HDAC inhibitor deficit present, that is consistent with dementia.6,174 As many as 1 2% of MCI cases per year have been found to progress to dementia over the course of 4 years.6 AAMI is a concept developed by a National Institute of Mental Health (NIMH) workgroup175-176 attempting to label the memory loss associated with normal aging.