Ally by prostaglandin Evodiamine Isoevodiamine production in a paracrine mechanism. With steroid therapy Not letrozole caused an inhibition of the enzymatic activity of t Aro and thus block the conversion of T Estrogens. The action of this drug tr Gt to an increase Increase in blood levels of androgens and therefore a reduction of estradiol. And androgens Estrogens are each capable of Ver are Changes the normal growth of the prostate, but they alone do not cause this, a b Sartigen tumor of the prostate. Some studies have shown that the combination of these two hormones, stero Of sex can lead to dysplasia, pr Kanzer lead Sen and cancerous prostate cells. Rivas et al.
suggest that the balance has fallen in action between androgens and estrogens, t as their absolute levels, may of fundamental importance for the normal and abnormal development of certain regions of the male pattern reproductive organs as may be reduced androgen action sensitizes the tissue to estrogen. The rodents Meriones unguiculatus Mongolian gerbil has been cited as a good model for the laboratory since the 1960s known. The usefulness of this animal in biomedical research in various areas of au Been recognized OUTSIDE of prostate morphology, and, more recently, the gerbil has been proposed to also be a suitable model for studies on aging ugetieren at S. Gerbil prostate has compact lobes, Similar to the human prostate, but in contrast to those of rats and mice M, Have the distinct lobes.
Based on the concept that the metabolism of stero R umlichkeiten Crucial in determining the overall impact of biological hormones in people, the normal and abnormal cells of the prostate is the goal, we tried to characterize by this study that the absence of the 5 R and Aro enzymes in the prostate-cellular Ren and extracellular Ren compartments according to their long-term inhibition and how prostate may need during the reaction of the tissue after the treatment of drug suspension restored. The main objective of this study was to investigate the Fa What is finasteride and letrozole were the microenvironment of the prostate on the three different stages of postnatal development gerbil base to st Ren. Young m Nnliche Rennm Mice 100, 100 adults and 100 years were housed in controlled conditions Lee’s temperature, relative humidity and lighting, and allowed free access to standard chow and water.
Treatment of animals and experiments were performed in accordance with the ethical guidelines of the Committee for Ethics in animal experimentation at UNICAMP in Campinas State University, your o Paulo, Brazil, according to the guidelines for the care and use of laboratory animals. The animals were again U orally for 30 days in a row, simultaneously or separately, R 5a finasteride inhibitor, on the basis of the results already from Corradi et al. Inhibitor letrozole and Aro, as described by Tobin and Canny and Santos et al. As a control group On, have some animals were endured intact, w While others again U as a vehicle for the same 30 days. The animals were 1, 7, get 14 Tet and 21 days after the end of time of drug administration, are the time of the post-processing. In each of these four steps at once Sthesiert by inhalation of CO2, Wstenrennm Mice experimental group and controlled Were weighed and decapitated, after which blood samples were collected for serological analysis. Prostatectomy