N collected levels of nitrite dialysate from the striatum and hippocampus was about one third to two thirds h and 2 h after treatment HBO2. In this study, L NMMA 30 minutes after end of treatment, HBO2 and administered 30 minutes prior to testing in bo You light / dark. If short, the rise of the NO, why inhibition of NOS antagonism after the fact because of the effect of HBO2 There was no measurement of NO or nitrite / nitrate levels 1 h after treatment HBO2. These values are likely to be site specific in the brain has not yet been established. But the Dev Rtstrend, but still significant Ver Change in the nitrite content in the dialysate and Elayan al. study seem to approx hre duration of angstl send effect of HBO2 as at least 3.0 atm. A second point is that L NMMA, a non-selective NOS, was used in this study, uct and to the blocking of all three isoenzymes of NOS to weight. Other studies have non-neuronal forms of NOS in behavioral responses implied. For example, it was shown that the selective inhibition of NOS fear as the behavioral response by transient cerebral ish In chemistry obtained Hten maze and social interaction test induces reduced. This fear- Similar reaction was the selective inhibitor ethylisothiourea inducible NOS blocked S, but not the neuronal NOS inhibitor 7 or selective iNOS satisfied with t that HDAC inhibitions nNOS in anxiogenesis. Conversely, it was reported that the anxiolytic effect as nitric oxide were sensitive to antagonism by methyl Lthiocitrulline, the selective inhibitor of neuronal NOS S, but not of normal doses of the endothelialselective inhibitor L ornithine N5 or the selective inhibitor of 2-amino-dihydro-6 inducible 5.6 1.3 thiazine methyl 4H. A third disadvantage is that there are reports of a m Aligned anxiogenic effect of NO. Results from other laboratories have shown that NOS inhibitors may evoke behavioral responses, such as anxiolytic alone.
It was observed that ODQ alone did, as angstl Send in the answers obtained Hten maze test and Vogel. This is also consistent with the conclusion from this study indicate that ODQ alone, a significant increase in the H He time in the light compartment of the box causes spent You light / dark. There is a dichotomy of embarrassing evidence is thatno promoter and inhibitor of neurogenesis, pronociceptive and antinociceptive, anticonvulsant and proconvulsant, neuroprotective and neurotoxic and thermogenic and thermolytic. A plausible explanation Tion for these differences lies in the Double R The NW as inmultiple signalingmolecule and m Counteract possible enough, the neural pathways. Many plants that have been traditionally used ALK Signaling Pathway pharmacological properties with big em potential therapeutic applications in the treatment of diseases of the central nervous system such as Angstst disturbances. Achillea millefolium L. Yarrow is known as a mehrj Hrige plant that has been used for hundreds of years of change in folk medicine in various countries. Germany and Italy, it will be used to treat gastrointestinaldisturbances. In Gro Kingdom and North America, it is used to treat bleeding. In Brazil, the main indication is the treatment of pain, injury, inflammation and gastrointestinal complaints, even though the plan.