Several

authors have suggested that low adherence to home exercises after discharge is one of the main reasons for the poor long-term effectiveness of exercise in people with osteoarthritis (Marks et al 2005, Pisters et al 2007, Roddy et al 2005). In order to continue exercise after the cessation of an exercise program, it has been suggested that exercises should be task-oriented and include strategies to change behaviour and encourage self-regulation skills Z-VAD-FMK nmr (Veenhof et al 2005). Home exercises that simulate the conditions of daily tasks should enhance adherence to home exercises after discharge and lead to a more physically active lifestyle. Veenhof and colleagues recently developed and evaluated an exercise program based on these principles called the ‘behavioural graded activity’ program (Veenhof et al 2006). This program consists of a period of facility-based intervention followed by booster sessions. It uses principles of operant conditioning (Fordyce et al 1973, Lindstrom et al 1992) and self-regulation (Leventhal et al 1987) and includes booster sessions to improve and maintain adherence (Noland 1989). The program is directed at enhancing exercise adherence and gradually increasing the amount of physical activity in a time-contingent way so that activities are gradually increased by http://www.selleckchem.com/products/AP24534.html preset quotas regardless of impairments, eg, increasing walking time by 2 minutes

per day despite the amount of pain. The ultimate goal is integration of these

activities into daily living, so that patients develop a more physically active lifestyle. Earlier research has shown that both behavioural graded activity and physiotherapy intervention according the Dutch guideline (Vogels et al 2001) result in benefits in terms of pain and physical function measured by WOMAC (Veenhof et al 2006). Long-term benefits in terms ADP ribosylation factor of walking and physical function measured by MACTAR-questionnaire were also found. However, it remains unclear if behavioural graded activity succeeds in increasing adherence and physical activity. Therefore, the research questions for the present study were: 1. Does behavioural graded activity result in better exercise adherence than usual care in people with osteoarthritis of hip and/or knee? An analysis of secondary outcomes of a behavioural graded activity trial was performed (Veenhof et al 2006). This trial was a single-blind cluster-randomised trial comparing a behavioural graded activity with usual care according to the Dutch physiotherapy guideline in patients with osteoarthritis of hip and/or knee. To avoid contamination between the interventions, cluster randomisation was performed at the level of centres, ie, physiotherapy practices. The centres were randomly allocated to deliver one of the two interventions by means of a computer-generated random sequence.