The concept of enzybiotics is very promising in this regard [4]. The term enzybiotic is a hybrid word from “enzyme” and “antibiotic”

that has been coined to designate bacteriophage lytic enzymes endowed with the capacity to degrade bacterial cell wall and with antibacterial Talazoparib in vivo potential [5]. The concept of enzybiotics was subsequently shown to be wider than first though, and nowadays it refers to all enzymes that are able to cause microbial cell death (endolysins, bacteriocins, autolysins and lysozymes) and regardless of their origin (including antifungal enzymes, antimicrobial peptides and enzymes that block peptidoglycan layer synthesis) [6]. Alternative names used with respect to enzybiotics are lytic enzymes or peptidoglycan hydrolases, as enzymatic cleavage of bacterial cell wall peptidoglycan (resulting in cell lysis) represents {Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Selleckchem Anti-infection Compound Library|Selleckchem Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|buy Anti-infection Compound Library|Anti-infection Compound Library ic50|Anti-infection Compound Library price|Anti-infection Compound Library cost|Anti-infection Compound Library solubility dmso|Anti-infection Compound Library purchase|Anti-infection Compound Library manufacturer|Anti-infection Compound Library research buy|Anti-infection Compound Library order|Anti-infection Compound Library mouse|Anti-infection Compound Library chemical structure|Anti-infection Compound Library mw|Anti-infection Compound Library molecular weight|Anti-infection Compound Library datasheet|Anti-infection Compound Library supplier|Anti-infection Compound Library in vitro|Anti-infection Compound Library cell line|Anti-infection Compound Library concentration|Anti-infection Compound Library nmr|Anti-infection Compound Library in vivo|Anti-infection Compound Library clinical trial|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|buy Antiinfection Compound Library|Antiinfection Compound Library ic50|Antiinfection Compound Library price|Antiinfection Compound Library cost|Antiinfection Compound Library solubility dmso|Antiinfection Compound Library purchase|Antiinfection Compound Library manufacturer|Antiinfection Compound Library research buy|Antiinfection Compound Library order|Antiinfection Compound Library chemical structure|Antiinfection Compound Library datasheet|Antiinfection Compound Library supplier|Antiinfection Compound Library in vitro|Antiinfection Compound Library cell line|Antiinfection Compound Library concentration|Antiinfection Compound Library clinical trial|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening| their major mode of action. Group of peptidoglycan hydrolases consist of diverse enzymes that can be obtained from various sources. Major groups of enzybiotics include endolysins (from phages) [7, 8]; autolysins and bacteriocins (produced by bacteria) [9, 10]; and lysozymes (from various

organisms) [11]. Amongst them, the phage endolysins held and still hold the special position as ultimate enzybiotics. Endolysins or lysins are enzymes encoded by double-stranded DNA bacteriophages, actively produced toward the end of the phage lytic cycle to break down Methane monooxygenase the

bacterial cell wall for phage progeny release [12]. They target the integrity of the cell wall and attack major bonds in the peptidoglycan. Depending on their enzymatic properties, lysins fall into five major classes: (i) N-acetylmuramoyl-l-alanine amidases; (ii) endopeptidases; (iii) N-acetyl-β-d-glucosaminidase; (iv) N-acetyl-β-d-muramidases (lysozymes) and (v) lytic transglycosylases [13]. Numerous experimental studies performed in vitro and in vivo on animal models have proved enzybiotics as highly effective antibacterial agents against variety of bacterial pathogens [14]. Moreover, other important aspects of enzybiotic therapy were examined, e.g. immunogenicity of enzybiotics [15], adverse effects and emergence of resistance [8, 12]. Bioinformatics is playing an important role in many aspects of drug discovery, drug assessment and drug development [16]. Biological databases covering genomic, proteomic and functional information have become significant in antimicrobial drug research. All information about representative enzybiotics and outcomes of their therapeutic application are dispersed among scientific papers and various biological databases. Recently, EnzyBase database has been published [17], collecting references and description of enzybiotics present in UniProt/Swiss-Prot database.