The dependent variable was the dichotomous variable the occurrence or non occurrence of LO BSI. Thereafter, a formal model of logistic regression was constituted to estimate the parameters using the quasi Newton method. Analysis selleck chem Perifosine of the individual p values allowed us to reject variables that were statistically insignificant. Before deciding to remove a variable, a logistic regression Inhibitors,Modulators,Libraries was performed separately for each factor. The Clinical Risk Index for Babies score, and Apgar 1 and 5 minutes scores were also included in the logistic model. The odds ratio was used to determine the effect of a specific factor to increase the likelihood of LO BSI.

A generalized linear model was Inhibitors,Modulators,Libraries applied to assess the significance of differences between Staphylococcus aureus, the coagulase negative staphylocci , Enterobacteriaceae and other microorganism infection, and birth weight, gestational age, duration of hospitalization prior to the date of onset of the initial clinical sign or used of devices CVC, PVC, mechanical Inhibitors,Modulators,Libraries ventilation, and or continuous positive airway pressure. These models were evaluated separately for each bacterial groups. As the dependent variable was dichotomous, the binominal distribution was used. The predictors used in the model were continuous, as well as, the categorical variables. Including such a set of variables in this model demands using the logit linked function. Calculations were performed with the application of the open source library SciPy. A multivariate analysis of the influence of the risk factors on CVC BSI identification was conducted using a classification tree learner.

A p 0. 05 was considered statistically significant. Our data Inhibitors,Modulators,Libraries were compared with NeoKISS surveillance system in Germany. In this analysis, data from one of six centers were not used because information about CVC and or PVC catheterization, MV and or CPAP was incomplete. NeoKISS data were chosen for comparison to the data from the PNSN owing to the meticulous research methods employed in this surveillance program. Results Description of the population There were 1,695 newborns included in our surveillance of whom 1,243 who survived 72 hrs. This group was composed of 462 of extremely low birth weight infants with a birth weight 750gms, 313 infants with a birth weight from 751 to 999 gm, and 920 infants with birth weight ranging from 1000 1500 gm.

Among these 1243 infants, 164 underwent surgical procedures. The most common surgical procedure was closure of the patent ductus arteriosus which represented 48. 4% of all surgical procedures. Late onset bloodstream infections There were 427 episodes of LO BSI diagnosed representing an incidence density of 6. 7 1000 Inhibitors,Modulators,Libraries patient days, including 46 cases of clinical sepsis were observed. The onset of clinical signs of LO BSI occurred an average of 15 days after birth. Mean gestational age was 28 weeks check this and the mean birth weight was 1100 grams.