The incidence of DFSP is thought to be 4.2 per million people annually in North America, with the vast majority of cases (42%) occurring in the truncal area and the remainder in the upper extremity, lower extremity, head and neck (83). DFSP appears as a solid, nodular polypoid tumor almost always arising from the dermis, with invasion into the subcutaneous tissue. Microscopically, it is characterized by a whorl-like spindle cell pattern of monomorphic fibroblast growth, accompanied usually by a low mitotic activity. In

cases where Inhibitors,research,lifescience,medical the subcutaneous layer is invaded there is often evidence of entrapment of adipose tissue between extending “limbs” of fibroblast growth. Immunohistochemically, DFSP lesions often exhibit vimentin and CD34 reactivity with occasional focal actin staining and are often negative for factor XIIIa, keratin and S-100 proteins (86). The treatment of DFSP is surgical and the standard is wide local excision with at least 2 cm margins (87). Given the Inhibitors,research,lifescience,medical high recurrence rate, a negative margin is of outmost importance but is hard to achieve in areas close to critical perineal structures such as the anal sphincters and therefore MMS should be considered, especially for small, distal and superficial

lesions (88). There have been numerous analyses comparing Inhibitors,research,lifescience,medical wide excision to MMS for other disease sites, most with small patient numbers and varying outcomes. A retrospective review comparing the two in 48 patients concluded that although MMS provided fewer incidences of positive margins, it also required longer operative time, higher cost and a higher incidence of complex closure requiring graft or flap (89). Given that 90% of DFSP cases have a t[17;22] chromosomal translocation Inhibitors,research,lifescience,medical and over expression of the (PDGF) gene explained previously, clinical Inhibitors,research,lifescience,medical trials with imatinib mesylate have recently been conducted. In a pool of

24 cases from two phase II trials in which daily imatinib was given to patients with locally advanced or Selleckchem Gammasecretase inhibitor metastatic DFSP, 45.9% of the patients showed at least partial response (90). These trials and other reports set the ground for the use of imatinib in the neoadjuvant setting and a phase II trial of 21 patients with positive fusion gene “COL1A1 & PDGF” (91). Eight patients (31%) had complete or partial response with a median 20% decrease Resveratrol in size. This limited data opens the possibility of considering imatinib mesylate preoperatively for anorectal DFSP, in cases where the extent of excision is an issue. There are only two reported cases of DFSP involving the anorectal region (92,93). One was a four year old child with no co-morbidities and a background history of trauma to the region. The tumor initially involved the right scrotum and then extended onto the anal margin. The lesion was excised using Mohs micrographic surgery (MMS) (92).