The total score was calculated by adding up individual answers and normalising the total score to a 100-scale, 0 representing CX-6258 the best and 100 the worst quality of life. The median domain EPZ015938 scores with interquartile range for the IOF-wrist fracture questionnaire, Qualeffo-41 (spine) and the EQ-5D are shown in Table 2. The discriminatory capacity of the 12 questions of the IOF-wrist questionnaire is shown in Table 3. Odds ratios for being in the patient group rather

than in the control group were high and significant. The discriminatory capacity of the IOF-wrist and Qualeffo-41 domain scores is shown in Table 4 and Fig. 1. The discriminatory capacity was high except for the pain domain of Qualeffo-41. Table 2 Median domain score and IQR   No. of questions in domain N Controls, median (IQR) N Cases, median (IQR) IOF-wrist  Pain 1 56 0 (0, 0) 104 50 (25, 50)  Upper limb symptoms 3 57 0 (0, 0) 104 25 (8, 42)  Physical function 7 71 0 (0, 3.6) 105 75 (61, 93)  General health 1 58 0 (0, 0) 92 75 (50, 75)  Overall score 12 71 0 (0, 2.1) 105 60 (50, 73) Qualeffo-41 (spine)  Pain 5 73 0 (0, 25) Nutlin-3a research buy 105 5 (0, 40)  Physical function 17 74 6 (1, 12) 105 47 (31, 60)  Social function 7 74 20 (7, 36) 105 50 (33, 63)  General health 3 74 42 (33, 58) 105 58 (42, 75)  Mental health 9 74 28 (19, 39) 105 39 (22, 64)  Overall score 41 74 18 (12, 23) 105 43 (32, 55) EQ-5D  Overall score 5 73 0.85 (0.73, Ergoloid 1.00) 104 0.59 (0.26, 0.72) Lower scores indicate better quality of life and higher scores indicate worse quality of life, with the exception of the EQ5D overall score where the reverse is true Table 3 Discriminatory capacity of IOF-wrist questions IOF-wrist

question N Unadjusted Adjusteda OR (95% CI) p value OR (95% CI) p value Do you still have pain in the fractured forearm or hand? 160 69.9 (18.0, 272) <0.001 211 (31.6, 1413) <0.001 Do you have numbness or “pins and needles” in the fractured forearm or hand? 160 9.9 (3.5, 27.7) <0.001 11.1 (3.7, 33.0) <0.001 Do you have stiffness in the fractured forearm or hand? 157 13.7 (4.8, 38.9) <0.001 14.8 (5.1, 42.9) <0.001 Are you disturbed by the deformity of your fractured forearm? 154 7.5 (2.9, 19.9) <0.001 8.4 (3.1, 23.2) <0.001 Can you wash or blow dry your hair? 174 34.0 (9.6, 121) <0.001 47.4 (11.8, 190) <0.001 Can you turn a door key or unscrew the lid of a jar? 176 8.4 (4.4, 15.9) <0.001 9.0 (4.6, 17.6) <0.001 Do you have problems with doing your work or home work? 176 9.3 (4.9, 17.8) <0.001 9.8 (5.0, 19.1) <0.