These transient changes in the neural aftereffects of stop-errors might be related to previous behavioral observations of PES after short, but not long response-stimulus intervals. (C) 2012 Elsevier Ltd. All rights reserved.”
“Introduction:
In lung transplantation (LTx), the arterial partial pressure of oxygen (PaO2) is traditionally regarded as critical information for assessment of donor lung function. Each center sets its own thresholds; by convention, a donor PaO2 of less than 300 mm Hg has been considered disqualifying. Limited literature exists to support such a practice. We analyzed all LTxs performed in the United States over a 9-year period to assess the effect of donor PaO2 on graft survival.
Methods: The United Network for Organ Sharing (UNOS) database was queried for LTx (January 2000-November 2009). Of 12,545 LTx performed, 12,045 (96%) had donor PaO2 data on a fraction of inspired oxygen of 1.0, recorded at the time Belnacasan of procurement.
Results: Mean donor PaO2 was 407 +/- 140 mm Hg. The majority of LTxs had a donor PaO2 greater than 300 mm Hg (9593 (80%]) whereas PaO2 was 200 mm Hg or less in 1830 (15%) and 201 to 300 in 582 (5%) donors. Use of donors with a PaO2 of less than 200 increased over time from 5% (45) in 2000 to 21% (295) in 2009 (P=.002). Kaplan-Meier survival analysis showed
no difference in graft survival with differing donor PaO(2)s, irrespective of whether patients had a single or double LTx. A Cox multivariable analysis of 21 donor characteristics demonstrated that donor PaO2 had no association with DMH1 graft survival.
Conclusions: Donor PaO2 levels did not affect graft survival. The use of donors with lower PaO(2)s could substantially increase the donor pool. We are not suggesting that donor PaO2 is not important when assessing potential lung donors but its level of importance in regard to other criteria appears less than previously believed. (J Thorac Cardiovasc Surg 2012; 143: 919-25)”
“Objective:
To determine if ambulatory blood pressure (ABP) at night relative to day ABP among adolescents is influenced by unfair treatment and trait anger, and whether Tozasertib clinical trial these associations are stronger in African Americans and adolescents from lower socioeconomic status (SES) families and neighborhoods Methods: A total of 189 healthy white and African American adolescents (ages = 14-16 years, standard deviation = 0 62, 50% female) completed 2 days and I night of ABP monitoring and unfair treatment and trait anger questionnaires SES was measured using 1) parental education and 2) a composite neighborhood SES score based on U S Census tract data for neighborhood poverty and education The night/day ABP ratio was calculated by dividing the night ABP mean (readings from the self-reported bedtime of each participant through 5 AM) by the clay ABP mean (8:30 AM until self-reported bedtime).