12 h in this phase I study, no significant toxicity t Drogenkriminalit T observed at the 100 or 200 mg doses, and have pharmacokinetic data suggest that these doses has been completed Born to drug exposure low, therefore, the dose to 800 mg twice t Ht was like for 7 days increased. On this level, the dose-limiting toxicity of PS-341 Bortezomib t including normal reversible Hypokali Chemistry, Hyponatri Chemistry, increases hte GGT, hyperglycemia Chemistry and reported rash generalized vasculitis. In addition, a rapid increase in creatinine w During the administration period h Observed frequently. Although this did not reach grade 3 and appear reversible after discontinuation of the drug, it was unexpected and of concern in the absence of a clear explanation Tion.
Similar toxicity Th in a separate Phase I clinical trial with 5 a day, twice are daily administration, oral schedule were been reported. In this study, creatinine, vomiting, skin rash, Hypokali Chemistry and grew up were also observed. The phase II recommended dose in this study is 2500 mg of t Possible BMS 794833 c-met inhibitor for 5 days, although this is reported to be associated with Hypokali Chemistry and manageable grade 3 rash degree 3. Pr Clinical toxicology has been reported, polydipsia and polyuria seliciclib related, but not kidney or Hypokali Chemistry. The pathogenesis of increased Hte creatinine is not completely Ndig understood, but with a reversible decrease in renal blood flow may be related. Some evidence was found from the analysis of serial MAG3 renograms isotopes a significant, reversible decrease in renal blood flow in a patient to receive seliciclib treatment.
The pathogenesis of Ver Change in renal blood flow can not be explained rt. It was suggested that the binding independently of seliciclib to Independent objectives such as AT9283 adenosine receptors to regulate the renal blood flow, k Nnten these results Ren explained, But this is not to date been CONFIRMS best. Reversibility t the Nierenfunktionsst Tion and the lack of supply changes In the urine retinol binding protein does not suggest, however, that this is not a clinically significant Tubulussch The association. Although much of the Nierenfunktionsst Tion that the two events are not always the same, Hypokali Doselimiting chemistry was also reversible w Observed during this study. This was observed at 200 mg potassium levels below 3.
0 mmol of 1 l were only at 800 mg potassium levels observed with less than 2.2 mmol in Figure 1, a patient. The Hypokali chemistry Was easily and rapidly reversible with potassium Erg Supplements you and stopping by seliciclib dosing. However, it was assumed that potentially found HAZARDOUS and it w re Well, watched very closely. The pathogenesis of Hypokali Chemistry has not been clarified Rt. Since the renal collecting duct and tubule It is important for the Hom Homeostasis of potassium, k These processes may be involved. Further studies on the effects of seliciclib on adenosine receptors, and carbonic anhydrase renal collecting duct Tubul Linear function and can be helpful. Pharmacokinetic data indicate that the level is not seliciclib were kept at the level associated with antitumor activity t in certain xenograft models. The mean maximum plasma concentration at the h Chsten dose was reached about 3 mgmL 1, w While mice with M, A maximum concentration of 100 mM seliciclib and about 24 h