The LOI designates the most appropriate care provider for women with defined medical or obstetric conditions.\n\nMethods: This descriptive study analysed the evolution of the concept of “normality” by comparing the development and the contents of the consecutive versions of the LOI from 1958 onwards. The results were related to data from available Dutch national databases concerning maternity care.\n\nResults: The number of conditions defined in the successive lists increased from 39 in 1958 to 143 in 2003. In the course of time, the nature click here and the content of many indications changed, as

did the assignment to the most appropriate care provider. The basic assumptions of the Dutch maternity care system remained

stable: the conviction that pregnancy and childbirth fundamentally are physiologic processes, the strong position of the independently practising midwife, and the choice between home or hospital birth for low-risk women. Nevertheless, the odds of the obstetrician being involved in the birth process increased from 24.7% Nutlin-3 in 1964 to 59.4% in 2002, whereas the role of the primary care provider decreased correspondingly.\n\nDiscussion: Multidisciplinary research is urgently needed to better determine the risk status and the optimal type of care and care provider for each individual woman in her specific situation, taking into account the risk of both under- and over-treatment. Safely keeping women in primary care could be considered one of a midwife’s interventions, just as a referral to secondary care may be. The art of midwifery and risk selection is to balance both interventions, in order to end up with the optimal result for mother and child. J Midwifery Womens Health 2010; 55: 216-225 (c) 2010 by the American College

of Nurse-Midwives.”
“Ji H. W., Li H. T., Zhu L., Zhang H., Wang Y., Zuo Z.C., Guo W.Z. & Xu Z.W. 2012. Development and evaluation of a loop-mediated isothermal amplification GSK1904529A order (LAMP) assay for rapid detection of Actinobacillus pleuropneumoniae based the dsbE-like gene. Pesquisa Veterinaria Brasileira 32(8): 757-760. Key Laboratory of Animal Biotechnology, Center of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, Sichuan, 625014, P. R. China. E-mail: [email protected]\n\nThis paper reports on the development and validation of a loop-mediated isothermal amplification assay (LAMP) for the rapid and specific detection of Actinobacillus pleuropneumoniae (A. pleuropneumoniae). A set of six primers were designed derived from the dsbE-like gene of A. pleuropneumoniae and validate the assay using 9 A. pleuropneumoniae reference/field strains, 132 clinical isolates and 9 other pathogens.

We demonstrate that it increases the signal-to-noise ratio of allelic

signals, making it significantly easier to detect allelic imbalances.\n\nConclusions: TumorBoost increases the power to detect somatic copy-number events (including copy-neutral LOH) in the tumor from allelic signals of Affymetrix or Illumina origin. We also conclude that high-precision allelic estimates can be obtained from a Barasertib molecular weight single pair of tumor-normal hybridizations, if TumorBoost is combined with single-array preprocessing methods such as (allele-specific) CRMA v2 for Affymetrix or BeadStudio’s (proprietary) XY-normalization method for Illumina. A bounded-memory implementation is available in the open-source and cross-platform R package aroma.cn, which is part of the Aroma Project (http://www.aroma-project.org/).”
“To compare the positions of the aorta

relative to vertebral bodies and ABT-263 ic50 the potential risk of the aorta impingement for pedicle screw (PS) placement between right-sided and left-sided thoracolumbar/lumbar curves of adolescent idiopathic scoliosis (AIS).\n\nThirty-nine AIS patients with a main thoracolumbar or lumbar curve were recruited. The Lenke’s classification was type 5C in all patients. According to the convexity of the thoracolumbar or lumbar curves, the patients were divided into either group R or Group L. The patients in Group R had a main right-sided thoracolumbar/lumbar curve, and the patients in Group L had a main left-sided thoracolumbar/lumbar curve. Axial CT images from T12 to L4 at the midvertebral body level were obtained to evaluate Aorta-vertebra angle (alpha), Vertebral rotation angle (beta), click here Lefty safety distance (LSD), and Right safety distance (RSD). The risks of the aorta impingement from T12 to L4 were calculated and then compared between the two groups.\n\nThe alpha increased from T12 through L4 in Group R, increased from T12 through L1, and then decreased from L1 through L4 in Group L. The beta decreased from T12 through L4 in both groups. The LSD constantly

increased from T12 through L4 in Group R, increased from T12 through L3, and then decreased from L3 through L4 in Group L. The RSD increased from T12 through L3 and then decreased from L3 through L4 in both groups. With the increment of the lengths of the simulated screws, the aorta impingement risks were constantly elevated at all levels in both groups. The aorta was at a high risk of impingement from left PS regardless of the diameters of the simulated screws in Group R (80-100 % at T12 and 53.3-100 % at L1). In Group L, the aorta was completely safe when using 35 mm (0 at all levels) PS and at high risks of the aorta impingement on the right side from 45 mm PSs (31.8-72.7 %). In all, the risks of the aorta impingement were mainly from left PS in Group R and from right PS in Group L, and the risk of the aorta impingement from PS placement was generally higher in right thoracolumbar or lumbar curves when compared with that of the left.

Results showed that soil bulk density in 0-20 cm soil layer decreased from 1.71 g cm(-3) in unreclaimed land to 1.44 g cm(-3) in reclaimed 3 yr fields, and saturated soil water content of 0-10 cm layer increased correspondingly from 20.3 to 30.2%. Both soil salinity and pH value in 0-40 cm soil layer dropped markedly after reclaiming 3 yr. Soil organic matter content reduced, while total nitrogen, total phosphorus, and total potassium all tended to increase after cropping and drip irrigation. The quantities of bacteria, actinomycete, and fungi in 0-40 cm soil layer all

greatly increased with increase of reclaimed years, and they tended to distribute homogeneously in 0-40 cm soil profile. The urease activity and alkaline phosphatase activity in 0-40 cm soil layers were also enhanced, but the sucrase activity was not greatly changed. These results indicated that after crop cultivation selleck chemicals and drip irrigation, soil physical environment and nutrients status were both improved. This was benefit

for microorganism’s activity and plant’s growth.”
“Ulmus pumila vary its water use strategy from seedling to maturity in a water-limited sandy land by adopting different photosynthetical capacities, water use efficiencies and morphological traits.\n\nRegeneration failure of natural Ulmus pumila populations has become a growing concern related to vegetation conservation and prediction of environmental change in the sandy lands of northern China. To better understand the life-history strategies of U. pumila Cyclosporin A and its adaptation to drought Screening Library in semiarid environments, we studied ecophysiological and morphological traits related to water use in an age sequence of U. pumila representing four age classes: current-year seedlings (Uc), age 2- to 5-year-old saplings (Us), juveniles (Uj), and mature trees (Um). A comparison of

hydrogen isotope data in xylem sap, soil water in different layers and groundwater showed that Uc relied on the soil water in the topsoil (0-40 cm), Us and Uj absorbed soil water from deeper soil (> 40 cm), while Um mainly used stable groundwater with very deep (> 2 m) taproots. Significantly lower predawn leaf water potentials were observed in Uc than in Uj or Um, suggesting that Uc experienced more severe water stress and had a weaker capacity to recovery. Moreover, Uc had the highest daily maximum net assimilation rate, daily maximum transpiration rate and daily maximum stomatal conductance, all of which decreased remarkably at midday. A “go for broke” strategy is probably practiced by Uc which try to provide the growth they need to become established, but with a great risk of mortality. Um used a more conservative strategy by effectively regulating the instantaneous water-use efficiency, and maintaining both stable gas exchange levels and significantly higher long-term water-use efficiency.

8; 95% CI, 1.1 to 2.9; P = .01), major hemorrhage (HR, 2.0; 95% CI, 1.0 to 3.9; P = .05), and myelofibrotic transformation BKM120 ic50 (HR, 5.5; 95% CI, 1.7 to 18.4; P = .0007) independently of known risk factors. Higher reticulin levels at diagnosis were associated with greater subsequent falls in hemoglobin levels in patients treated with anagrelide (P = .0001),

but not in those receiving hydroxyurea (P = .9). Moreover, serial trephine specimens in patients randomly assigned to anagrelide showed significantly greater increases in reticulin grade compared with those allocated to hydroxyurea (P = .0003), and four patients who developed increased bone marrow reticulin on anagrelide showed regression of fibrosis when switched to hydroxyurea. These data suggest that patients receiving anagrelide therapy should undergo surveillance bone marrow biopsy every 2 to 3 years and that those who show substantially increasing reticulin levels are at risk of myelofibrotic transformation and may benefit from changing therapy before adverse clinical features develop.\n\nConclusion\n\nOur results demonstrate that bone marrow reticulin grade at diagnosis represents an independent prognostic marker in ET, reflecting activity and/or duration of disease, with implications for the monitoring of patients receiving anagrelide. J Clin Oncol 27: 2991-2999. (C) 2009 by American Society of Clinical Oncology”
“From

July 4, 1999, when a liver transplantation AY 22989 program was started in Cuba, to December 30, 2007, we performed 125 procedures in 115 patients. The most frequent reasons for transplantation were cirrhosis caused by hepatitis C virus (29%) and alcoholic cirrhosis (17.2%). Two patients received simultaneous liver-kidney transplants. Sixty-seven patients were males, and the patient ages ranged from 12 to 74 years. The average surgical time was 6 hours, and cold ischernia time was 4 to

14 hours. The average blood consumption was 1630 mL; 2900 mL of plasma and 8 units of platelets were used in 7 cases. Immunosuppression was mainly cyclosporine, mycophenolate mofetil, and prednisone. Acute cellular rejections were treated in almost all cases with 3 doses of methylprednisolone. The most frequent complications were biliary (15%), hepatic arterial thrombosis (6%), postsurgical bleeding (8%), acute cellular rejection (20%), and check details ductopenic rejection (2%). The overall 1-year survival was 74.7%.”
“Background: Short-term results after proximal interphalangeal joint arthroplasty with pyrolytic carbon (pyrocarbon) implant have shown that this implant has high complication rates, but patient satisfaction is high. The authors evaluated the effectiveness of the implant for use in proximal interphalangeal joint at a minimum of 2 years of follow-up.\n\nMethods: Thirteen consecutive candidates who underwent 21 proximal interphalangeal joint arthroplasty procedures with pyrocarbon implant were evaluated prospectively.

Their activity as cationic photoinitiators was studied using real-time infrared spectroscopy. The results obtained showed that PhCH2PhFe+CpPF6- and PhCOPhFe+CpPF6- are capable of photoinitiating the cationic polymerization of epoxy monomer directly on irradiation with long-wavelength UV light. Comparative studies also demonstrated that PhCH2PhFe+CpPF6- exhibited better efficiency than I-261 and PhCOPhFe+CpPF6-. DSC studies showed that PhCOPhFe+CpPF6- and PhCH2PhFe+CpPF6- photoinitiators in epoxides possess good thermal

stability in the absence of light. (C) 2008 Elsevier B.V. All rights reserved.”
“Objective To assess the safety and efficacy of tetrahydrobiopterin therapy with sapropterin to treat tetrahydrobiopterin (BH4)-responsive

find more phenylalanine hydroxylase (PAH) deficiency in children aged smaller than 4 years compared with those aged bigger than = 4 years. Study design We analyzed a longitudinal follow-up study conducted in all patients with BH4-responsive PAH deficiency throughout Japan. At the end of 2011, 43 patients were receiving sapropterin, of whom 21 were aged smaller than 4 years at the initiation of treatment. The starting dose of sapropterin was bigger than = 10 mg/kg/day in 11 of these 21 patients. selleck chemicals The duration of follow-up was bigger than = 4 years in 6 of those 11 patients; 3 of these 6 were followed for bigger than = 10 years. Nine patients were receiving sapropterin monotherapy at the end of 2011. Results Serum phenylalanine level was maintained within the recommended optimal control range in all Bucladesine cost 21 patients who started sapropterin treatment before age 4 years. Only 1 nonserious adverse drug reaction

occurred, an elevated alanine aminotransferase level in 1 patient. No significant abnormal behavior related to nerve disorders was reported. Conclusion Sapropterin therapy initiated before age 4 years was effective in maintaining serum phenylalanine level within the favorable range and was safe in Japanese patients with BH4-responsive PAH deficiency.”
“Although usually assumed to be smooth and continuous, mammalian cochlear frequency-position maps are predicted to manifest a staircase-like structure comprising plateaus of nearly constant characteristic frequency separated by abrupt discontinuities. The height and width of the stair steps are determined by parameters of cochlear frequency tuning and vary with location in the cochlea. The step height is approximately equal to the bandwidth of the auditory filter (critical band), and the step width matches that of the spatial excitation pattern produced by a low-level pure tone. Stepwise tonotopy is an emergent property arising from wave reflection and interference within the cochlea, the same mechanisms responsible for the microstructure of the hearing threshold.

\n\nResults: We found 1359 incident AF events in 100 074 person-years LY3023414 nmr of follow-up. Unadjusted 5-year event rates differed by cohort (AGES, 12.8 cases/1000 person-years; CHS whites, 22.7 cases/1000 person-years; and FHS, 4.5 cases/1000 person-years) and by race (CHS African Americans, 18.4 cases/1000 person-years). The strongest risk factors in all samples were age and heart failure. The relative risks for incident AF associated with risk factors were comparable across cohorts and race groups. After recalibration for baseline incidence and risk factor distribution, the Framingham algorithm, reported in C statistic, performed reasonably well in all samples:

AGES, 0.67 (95% confidence interval [CI], 0.64-0.71); CHS whites, 0.68 (95% CI, 0.66-0.70); and CHS African Americans, 0.66 (95% CI, 0.61-0.71). Risk factors combined in

the algorithm explained between 47.0% (AGES) and 63.6% (FHS) of the population-attributable risk.\n\nConclusions: Risk of incident AF in community-dwelling whites and African Americans can be assessed reliably by routinely available and potentially modifiable clinical variables. Seven risk factors accounted for up to 64% of risk.”
“By means of a multicentre retrospective study based on the failure of 418 aseptic Selleckchem CUDC-907 unicondylar knee arthroplasties (UKA) our aims were to present the different types of revision procedure used in failed UKAs, to establish a clear operative strategy for each type of revision and to better define the indications for each type of revision.\n\nAseptic loosening was the principal cause of failure

(n = 184, 44 %) of which 99 cases were isolated tibial loosening (23.5 % of the whole series and 54 % of all loosening), 25 were isolated femoral loosening (six and 13.6 %) and 60 were both femoral and tibial loosening (14.3 and 32.6 %). The next most common causes of failure were progression of arthritis (n = 56, 13.4 %), polyethylene wear (n = 53, 12.7 %), implant positioning errors (n = 26), technical difficulties (n = six) and implant failure (n = 16, 3.8 % of cases). Data collection was performed online using OrthoWave https://www.selleckchem.com/products/AZD7762.html (TM) software (Aria, Bruay Labuissiere, France), which allows collection of all details of the primary and revision surgery to be recorded.\n\nA total of 426 revisions were performed; 371 patients underwent revision to a total knee arthroplasty (TKA) (87 %), 33 patients (7.7 %) were revised to an ipsilateral UKA, 11 (2.6 %) patients underwent contralateral UKA (ten) or patellofemoral arthroplasty (one) and 11 patients (2.6 %) underwent revision without any change in implants.\n\nBefore considering a revision procedure it is important to establish a definite cause of failure in order to select the most appropriate revision strategy.

2]paracyclophanyldiazonium GANT61 mouse fluoborate 2a through a heterolytic cleavage process gave products with partial racemization. In contrast, dediazoniation reactions of (S-p)-2a undergoing a nonheterolytic cleavage process afforded

products with retention of configuration. A key intermediate, the bromonium cation B, caused the racemization. The unexpected racemization allowed the mechanisms of the dediazoniation reaction to be probed.”
“Background and Purpose: Laparoendoscopic single-site (LESS) surgery has been implemented recently in many laparoscopic (LAP) surgical procedures. We report our initial experience with LESS totally extraperitoneal (LESS-TEP) inguinal hernia repair in relation to conventional LAP-TEP.\n\nPatients and Methods: Between

November 2008 and May 2009, 25 LESS-TEP repairs of inguinal hernia and 29 LAP-TEP repairs of inguinal hernia were performed in 44 patients. Data regarding patient demographics, type of hernia, operative time, complications, postoperative hospital stay, and recurrence were prospectively collected and analyzed.\n\nResults: All 44 patients were men, aged 17 to 84 years. Of 44 men, 3 had bilateral inguinal hernias in the LESS-TEP group and 7 in the LAP-TEP group. The operative time for bilateral LESS-TEP was 60 +/- 15.3 min (range 40-70 min) and 40 +/- 21.6 min (range 20-100 min) for unilateral LESS-TEP, while for bilateral hernia LAP-TEP it was 60 +/- 24.8 min (range 40-100 min) and for unilateral LAP-TEP it was 50 +/- 14.2 min (range 40-80 min). Comparison of operative times in the LESS-TEP and LAP-TEP groups between the first and second half cohort resulted in significant Ulixertinib clinical trial reduction of operative time in the second half of the LESS-TEP

group (P < 0.001). There were no intraoperative complications. Discharge was within 72 hours for most patients in both groups. There was one early recurrence (mesh displacement) during a median follow-up period of 11.5 +/- 2.5 months in the LESS-TEP group and no recurrences during the 11 +/- 1.6 months in the LAP-TEP group.\n\nConclusion: In our experience, LESS-TEP is a safe and feasible procedure with a short learning curve. In all analyzed parameters, it is comparable to conventional LAP-TEP. Further studies that compare LESS-TEP and conventional multiport LAP-TEP repairs with long-term follow-up evaluation are GM6001 solubility dmso needed to confirm the initial experience.”
“Aim The study investigated whether autophagic activity and hypoxia parallel the adenomacarcinoma sequence. Method The study comprised 120 tubular adenomas with high-grade dysplasia, including 22 with questionable evidence of invasion, 37 with definite stromal invasion and 29 with severely dysplastic adenoma, 10 traditional serrated adenomas and 22 classical tubular adenomas lacking aggressive features. The samples were stained immunohistochemically for autophagy (LC3A and Beclin-1) and hypoxia-inducible factor1-alpha (HIF1) markers.

\n\nResults: Participants were significantly

more likely to recognise both hypo/manic and depressive early warning signs rather than only one type of mood episode. The ability to detect signs of both hypo/mania and depression was greater in younger participants. The ability to detect signs of depression was associated with more click here prior depressive episodes and a lesser likelihood of prior hospitalisations whilst a history of mixed mood was associated with a greater likelihood of detecting depressive symptoms. The ability to recognise signs of hypo/mania was greater in those reporting a history of visual hallucinations (during depressive and/or manic episodes).\n\nLimitations: Cross-sectional design and previous experience with psychotherapy was not assessed.\n\nConclusion: These findings provide useful clinical data pertinent to psychological AZD9291 interventions for bipolar disorder. Longitudinal studies are needed to further examine how the ability to recognise early warning signs may be associated with longer term outcome. (c) 2012 Elsevier B.V. All rights reserved.”
“Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a transcription factor that regulates cellular stress responses. While the

levels of HIF-1 alpha protein are tightly regulated, recent studies suggest that it can be active under normoxic conditions. We hypothesized that HIF-1 alpha is required for normal beta cell function and reserve and that dysregulation may contribute to the pathogenesis of type 2 diabetes (T2D). Here we show that HIF-1 alpha protein is present at low levels in mouse and human normoxic beta cells and islets. Decreased levels of HIF-1 alpha impaired glucose-stimulated ATP generation and beta cell function. C57BL/6 mice with beta cell-specific Hif1a disruption (referred to herein as beta-Hif1a-null mice) exhibited IPI-549 in vivo glucose intolerance, beta cell dysfunction, and developed severe glucose intolerance on a high-fat diet. Increasing HIP-1 alpha levels by inhibiting its degradation through iron chelation markedly

improved insulin secretion and glucose tolerance in control mice fed a high-fat diet but not in beta-Hif1a-null mice. Increasing HIF-1 alpha levels markedly increased expression of ARNT and other genes in human T2D islets and improved their function. Further analysis indicated that HIF-1 alpha was bound to the Arnt promoter in a mouse beta cell line, suggesting direct regulation. Taken together, these findings suggest an important role for HIF-1 alpha in beta cell reserve and regulation of ARNT expression and demonstrate that HIF-1 alpha is a potential therapeutic target for the beta cell dysfunction of T2D.”
“BACKGROUND\n\nAlthough bone mineral density (BMD) testing to screen for osteoporosis (BMD T score, -2.

Proteinaceous character was detected with both methods, in greater abundance for PLFA, which we attributed to its microbial source material and labile, potentially more reactive nature than

SRFA. Characterization from both analytical techniques resulted in complementary data that reinforce the importance of PLFA as an IHSS reference standard that should be utilized for other microbiological environmental DOM comparisons. (C) 2013 Elsevier Ltd. All rights reserved.”
“Background Exit interviews are widely used in healthcare organisations FDA-approved Drug Library clinical trial to identify reasons for staff attrition, yet their usefulness in limiting turnover is unclear. Objectives To determine the effectiveness of various exit interview strategies in decreasing turnover rates amongst healthcare professionals. Search methods We searched the Cochrane EPOC Group Specialised Register; Cochrane Central Register of Controlled Trials (CENTRAL), Issue 11,

2012; MEDLINE, Ovid (1950-); EMBASE, Ovid (1947-); CINAHL, EbscoHost (1980-), and PsycINFO, OVID (1806-) between October 31 and November 6, 2012. We also screened the reference lists of included studies and relevant reviews; and searched trial registries for planned and on-going trials. We did not restrict searches by language or publication date. Selection criteria Randomised controlled trials, controlled clinical trials, controlled before-after studies and interrupted time series studies comparing turnover rates between healthcare professionals who had undergone one form of exit selleck products interview with another form of exit interview

or with no interview. Data collection and analysis Two review authors independently assessed trial quality and extracted data. Main results The original search identified 1560 citations, of which we considered 19 potentially relevant. The two authors independently reviewed the abstracts of these studies and retrieved the full texts of eight studies. We excluded all eight following independent assessment; they were either interviews, commentaries on how to do an exit interview or descriptive studies about reasons for leaving. We found no trials that matched our inclusion criteria. For this first CT99021 update, we screened 2220 citations and identified no new trials. Authors’ conclusions Evidence about the effectiveness of exit interviews to reduce turnover is currently not available. However, exit interviews may provide useful information about the work environment which, in turn, may be useful in the development of interventions to reduce turnover.”
“The vertebrate heart develops from mesoderm and requires inductive signals secreted from early endoderm. During embryogenesis, Nkx2.5 acts as a key transcription factor and plays essential roles for heart formation from Drosophila to human. In mice, Nkx2.5 is expressed in the early first heart field, second heart field pharyngeal mesoderm, as well as pharyngeal endodermal cells underlying the second heart field.

2 x 10(5) among specimens with complete MLST profiles compared with 1.3 x 10(4) among specimens without complete MIST profiles; all specimens with complete profiles had at least 4.9 x 10(4) Leptospira/mL (t = 5, P < 0.001). Most (11/12) identified sequence types were ST1 (L. interrogans serovar Lai) and ST44 (L. interrogans serovar Geyaweera). MLST can be used to directly identify infecting Leptospira strains in blood samples obtained during acute illness without the need for culture isolation, but it shows important limitations related to bacterial load.”
“Cancer is an DAPT in vitro increasing and major problem after solid organ transplantation. In part, the increased cancer risk is associated

with the use of immunosuppressive agents, especially calcineurin inhibitors. We propose that the effect of calcineurin inhibitors on the expression of vascular endothelial growth factor (VEGF) leads to an angiogenic milieu that favors tumor growth. Here, we used 786-0 human renal cancer cells to investigate the effect of cyclosporine (CsA) on VEGF expression. Using a full-length VEGF promoter-luciferase construct, we found that CsA markedly induced VEGF transcriptional activation through

the protein kinase C (PKC) signaling pathway, specifically involving PKC and PKC delta isoforms. Moreover, CsA promoted the association of PKC zeta and PKC delta with the transcription factor Sp1 as observed by immunoprecipitation assays. Using promoter deletion constructs, we found that CsA-mediated VEGF transcription was primarily JQ1 Sp1 dependent. Furthermore, CsA-induced and PKC-Sp1-mediated VEGF transcriptional IWR-1-endo manufacturer activation was partially inhibited by von Hippel-Lindau protein. CsA also promoted the progression of human renal tumors in vivo, wherein VEGF is overexpressed. Finally, to evaluate the in vivo significance of CsA-induced VEGF overexpression in terms of post-transplantation tumor development, we injected CT26 murine carcinoma cells (known to form angiogenic tumors) into mice with fully MHC mismatched cardiac transplants. We observed that therapeutic

doses of CsA increased tumor size and VEGF mRNA expression and also enhanced tumor angiogenesis. However, coadministration of a blocking anti-VEGF antibody inhibited this CsA-mediated tumor growth. Collectively, these findings define PKC-mediated VEGF transcriptional activation as a key component in the progression of CsA-induced post-transplantation cancer.”
“Objective-To determine if elasticity in blood vessels is compromised in circadian clock-mutant mice (Bmal1-knockout [KO] and Per-triple KO) and if matrix metalloproteinases (MMPs) might confer these changes in compliance. Methods and Results-High-resolution ultrasonography in vivo revealed impaired remodeling and increased pulse-wave velocity in the arteries of Bmal1-KO and Per-triple KO mice.