Samples of peripheral blood and buccal mucosa cells were evaluated using the single-cell gel electrophoresis assay (comet assay) and the micronucleus (MN) assay, respectively. PM10

samples were collected in the target site and the organic matter extraced with dichloromethane was assessed for mutagenic activity in the Salmonella/microsome assay. The exposed group (n = 37) was compared to a reference group (n = 37) of subjects living in an urban area with limited traffic and industrial influence, located far from the main industrial areas. All PM10 organic extracts showed mutagenic positive responses and the effect decreased in the presence of S9 mix indicating that the predominant compounds present were direct-acting mutagens. The responses of YGs strains selleck chemical are consistent with aromatic amines and nitroarenes being present in the PM10 extracts. The group in the area under the influence of the oil refinery (exposed group) showed significantly higher DNA damage in lymphocytes than the reference group. The MN frequencies in buccal mucosa were very low for both groups and no difference between groups was observed. No association was found between age and tobacco smoking habit and level of DNA damages measured by the comet assay. The results indicate that the comet assay was a sensitive tool to detect

DNA damage in subjects under the influence of an oil refinery, with marked genotoxic

Navitoclax cell line activity in the atmospheric environment. (C) 2009 Elsevier Ltd. All rights reserved.”
“Objectives: To compare the efficacy of nasal antiseptic GW786034 ointment and silver nitrate cautery in the treatment of children with recurrent epistaxis.

Methods: In this prospective and randomized study, a hundred children with recurrent epistaxis were assigned into two groups. In group 1, patients underwent silver nitrate cauterization, in group 2 patients were treated with nasal antiseptic ointment (oxytetracycline hydrochloride-polymyxin B sulfate); and both groups were followed for 3 months. All of the patients were investigated for allergy with skin prick test.

Results: The ages of patients were similar in both groups (group 1:9.2 +/- 2.7; group 2:8.2 +/- 2.2; p = 0.069). Thirty-eight percent of the patients in group 1 and 52% of the patients in group 2 had epistaxis in the three months follow-up. The difference between groups was not significant (p = 0.159). Thirteen (26%) of the patients in group 1 and 12(24%) of the patients in group 2 were found to have allergic symptoms and positive prick test. The rate of allergy was similar in both groups (p = 0.817).

Conclusion: Nasal antiseptic ointment and silver nitrate cauterization were found to have similar outcomes in the treatment of recurrent epistaxis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

The results show that in the functionalized device the carrier mobility is improved and does not depend on the high gate voltage. (C) 2011 American Institute of Physics. [doi:10.1063/1.3658846]“
“In the industrial operation of biotrickling filters for hydrogen sulfide (H(2)S) removal, shock loads or starvation was https://www.selleckchem.com/products/Vorinostat-saha.html common due to process variations or equipment malfunctions. In this study, effects of starvation and shock loads on the performance

of biotrickling filters for H(2)S removal were investigated. Four experiments were conducted to evaluate the changes of biomass and viable bacteria numbers in the biotrickling filters during a 24-d starvation. Compared to biomass, viable bacteria numbers decreased significantly during the starvation, especially when airflow was maintained in the absence of spray liquid. During the subsequent re-acclimation, all the bioreactors could resume high removal efficiencies within 4 d regardless Quisinostat in vivo of the previous starvation conditions. The results show that the re-acclimation time, in the case of biotrickling filters for H(2)S removal, is mainly controlled by viable H(2)S oxidizing bacteria numbers. On the other hand, the biotrickling filters can protect against shock loads in

inlet fluctuating H(2)S concentration after resuming normal operation. When the biotrickling filters were supplied with H(2)S at an input of lower than 1700 mg/m(3), their removal efficiencies mTOR inhibitor were nearly 98% regardless of previous H(2)S input.”
“The photoperiodic response is one of the adaptation mechanisms to seasonal changes of lengths of day and night. The circadian clock plays pivotal roles in this process. In Arabidopsis, LHY, CCA1, ELF3, and other clock proteins play major roles in maintaining circadian rhythms. lhy;cca1 double mutants with severe defects in circadian rhythms showed accelerated flowering under short days (SDs), but delayed flowering under continuous light (LL). The protein level of the floral repressor SVP increased in lhy;cca1 mutants under LL, and the late-flowering phenotype of lhy;cca1 mutants was partially suppressed

by svp, flc, or elf3. ELF3 interacted with both CCA1 and SVP, and elf3 suppressed the SVP accumulation in lhy;cca1 under LL. These results suggest that the unique mechanism of the inversion of the flowering response of lhy;cca1 under LL may involve both the ELF3-SVP/FLC-dependent and -independent pathways. In this work, elf3-1 seeds were mutagenized with heavy-ion beams and used to identify mutation(s) that delayed flowering under LL but not long days (LDs) or SDs even without ELF3. In this screening, seven candidate lines named suppressor of elf3 1 (self1), sel3, sel5, sel7, sel14, sel15, and sel20 were identified. Genetic analysis indicated that sel20 was a new deletion allele of a mutation in the blue light receptor, CRY2.

J Heart Lung Transplant 2011;30:460-6 (C) 2011 International Society for Heart and Lung Transplantation. All rights reserved.”
“Swift heavy ions impacting on matter lose energy through the creation of dense tracks of charges. The study of the space and time evolution of energy exchange allows understanding the single event effects behavior in advanced microelectronic devices. In particular, the shrinking of minimum feature

size of most advanced memory devices makes them very interesting test vehicles to study these effects since the device and the track dimensions are comparable; hence, measured effects are directly correlated with the time and space evolution of the energy release. In this work we are studying the time and space evolution of ion tracks by using advanced non volatile memories and Monte Carlo simulations. www.selleckchem.com/products/AZD6244.html Experimental results are very well explained by the theoretical calculations. (C) 2010 American Institute of Physics. [doi:10.1063/1.3514167]“
“To evaluate the role of high-dose dietary zinc in the process Screening Library screening of prostate malignancy, 60 Sprague-Dawley rats were randomly divided into four groups: tumor induction with carcinogen and hormone (group 1), oral zinc administration without tumor induction (group 2), oral zinc

administration with tumor induction (group 3) and a control without zinc administration or tumor induction (group 4). Zinc was supplied orally in the form of zinc sulfate heptahydrate dissolved in drinking water to groups 2 and 3 for 20 weeks. Although the serum level of zinc measured at 20 weeks was maintained similarly in each group (P = 0.082), intraprostatic zinc concentrations were statistically different. Group 1 prostates contained the least amount of zinc in both the dorsolateral and ventral lobes at levels of 36.3 and 4.8 mu g g(-1), respectively. However, in group 3, zinc levels increased in both lobes to 59.3

and 12.1 mu g g(-1), respectively, comparable with that of group 4 (54.5 +/- 14.6 and 14.1 +/- 2.4 mu g g(-1)). In spite BIX 01294 price of these increases in zinc concentration, the prevalence of prostate intraepithelial neoplasm was rather increased in group 3 (53.3% and 46.7%) compared with group 1 (33.3% and 33.3%) in both dorsolateral and ventral prostate lobes. Although prostate intraepithelial neoplasm did not develop in any prostate in group 4, zinc administration did induce prostate intraepithelial neoplasm in group 2 (46.7% and 40.0%). Thus, although high dietary zinc increased intraprostatic zinc concentrations, it promoted, instead of preventing, prostate intraepithelial neoplasm in a murine prostate malignancy induction model.”
“The HeartWare (HeartWare Inc, Framingham, MA) ventricular assist device (HVAD) is designed to be implanted with the pump in the pericardial space and its integrally attached inflow cannula in the left ventricle.

All patients achieved solid fusion.

Conclusion.

This case series demonstrates a safe, easy, and effective treatment regimen for the patients with primary basilar invagination.”
“The DMXAA nmr normal function of lymphatic vessels is to facilitate the trafficking of antigen presenting cells to draining lymph nodes where they evoke an immune response. Donor lymphatic vessels are not connected to that of recipients’ during organ transplantation. The pathophysiology of this disruption has received little attention. Murine heterotopic cardiac transplantation has been used extensively in transplantation research. Following vascularized organ transplantation, the main site of allosensitization is thought to be in the spleen of the recipient as a result of migration of donor passenger leukocytes via blood. Here, using Single Photon Emission Computed Tomography/Computerized Tomography (SPECT/CT) lymphoscintigraphy, we studied the pattern of lymphatic flow from mouse heterotopic abdominal cardiac grafts and identified mediastinal lymph nodes as the draining nodes for the donor graft.

Staining with HY tetramer after transplantation of HY mismatched heart grafts and ELISPOT following allogeneic grafts to detect donor specific T cells revealed them as important sites for allosensitization. Our data indicates that mediastinal lymph nodes play a crucial role in the alloimmune response in this model, and should be used for ex vivo and adoptive transfer studies click here after transplantation in addition to the spleen.”
“The aim of the study was to evaluate interictal electroencephalogram features in 22 patients with Dravet syndrome from the onset of the Selleck A-1331852 disease through the next 5 years. Electroencephalogram was abnormal in 5 patients (22.7%) at onset, and in 17 (77.3%) at the end of the study. Epileptiform abnormalities (focal, multifocal, or generalized) were seen in 6 patients at the onset and in 14 (27% vs 64%) at

the end of the study. Photoparoxysmal response was present in 41% of patients at the end of follow-up. No statistical differences were found between mutated and nonmutated groups regarding evolution of background activity, interictal abnormalities, and presence of photoparoxysmal response. Electroencephalogram findings seemed to be age dependent, variable among different patients, and not influenced by the presence of sodium channel, voltage-gated, type I, alpha subunit (SCN1A) mutation. The lack of specific epileptiform abnormalities contributes to the difficulty of patients’ management in Dravet syndrome.”
“Purpose of review Excessive bleeding is a common and morbid problem after cardiac surgery. There is no doubt a need for an effective and safe hemostatic agent in order to minimize transfusions and avoid surgical reintervention for hemostasis. Recombinant activated factor VII (rFVIIa) is being used (off-label) increasingly after cardiac surgery to prevent or to control hemorrhage, but its efficacy and safety remain unclear.

After preoperative evaluation including clinical and radiological

assessment and echocardiography, he underwent successful repair of a pseudoaneurysm of the ascending aorta by excision and replacement of the diseased aorta with a Dacron tube graft using cardiopulmonary bypass. Postoperatively, he was started on antituberculous chemotherapy based on histological findings.”
“A variety of exposure regimens of cigarette smoke have been used in animal models of lung diseases. In this study, we compared biological responses of smoke exposure in rats, using different smoke concentrations (wet total particulate matter [WTPM]), daily Selleckchem Screening Library exposure durations, and total days of exposure. As a range-finding acute study, we first compared pulmonary responses between SD and F344 strains BIX 01294 order after a single nose-only exposure to mainstream cigarette smoke or LPS. Secondly, F344 rats were exposed to cigarette smoke for 2 or 13 weeks under the comparable daily exposure dose (WTPM concentration x daily exposure duration; according to Haber’s rule) but at a different WTPM concentration or daily exposure

duration. Blood carboxylhemoglobin was increased linearly to the WTPM concentration, while urinary nicotine plus cotinine value was higher for the longer daily exposure than the corresponding shorter exposure groups. Gamma glutamyl transferase activity in bronchoalveolar lavage fluid (BALF) was increased dose dependently after 2 and 13 weeks of cigarette smoke exposure, while the neutrophil content in BALF was not increased notably. Smoke-exposed groups showed reduced body weight gain and increased VX-680 relative lung and heart weights. While BALF parameters and the relative lung weights suggest pulmonary responses, histopathological

examination showed epithelial lesions mainly in the upper respiratory organs (nose and larynx). Collectively, the results indicate that, under the employed study design, the equivalent daily exposure dose (exposure concentration x duration) induces equivalent pulmonary responses in rats.”
“Objective: Chronic neutropenia of childhood (CNC) is a rare disorder in which the absolute neutrophil count is below 1500/mu L over an extended period of time. The objective of this study is to describe the otolaryngolgic manifestations associated with CNC to facilitate diagnosis and treatment of this condition.

Methods and materials: We performed a retrospective chart review of patients with the diagnosis of CNC between 1970 and 2005 at a tertiary pediatric hematology center. After Institutional Review Board approval, 43 patients were evaluated. The average age at hematologic diagnosis was 49 months (range: 1 month – 15 years with 35% <1 year, 44% 1-10 years, 21% >10 years). A total of 2049 encounters were analyzed from the hospital charts.

(C) 2011 Elsevier Inc. All rights reserved.”
“Study Design. This is a validation study to evaluate validity and reliability of a translated and culturally adapted Neck Pain and Disability Scale (NPAD).

Objective. To conduct a cross-cultural adaptation and check the validity and reliability of a Chinese version of NPAD.

Summary ERK inhibitor cell line of Background Data. Neck pain and its associated disability are very common musculoskeletal problems. NPAD is a reliable evaluation instrument for neck

pain and disability, but there is no availability of a published Chinese version.

Methods. NPAD was translated into Chinese. To examine the psychometric properties and clinical application of the adapted Chinese NPAD, a survey was conducted in a group of 106 patients. The factor structure of NPAD was analyzed and subscales were defined. Reliability assessment was determined by calculating internal consistency and test-retest repeatability. Validity was decided by comparing the Chinese version of SF-36 to NPAD and conducting subscales

comparisons to single SF-36 domains.

Results. Factor analyses demonstrated four subscales for NPAD: “”pain,”" “”disability,”" “”neck-specific function,”" and “”emotional and cognitive influences.”" The internal consistency for “”pain,”" “”disability,”" “”neck-specific function,”" and “”emotional and cognitive influences”" subscales was 0.935, 0.952, 0.955, and 0.910, respectively. Test-retest reliability was also acceptable for the whole scale (r = 0.813, P < 0.001),

Selleck AG-881 GSK2879552 as well as for each of the four subscales. Construct validity was established through comparison with SF-36. All the subscales were significantly correlated with the SF-36 domains, except the items associated with Mental Health and Emotional Role.

Conclusion. The authors report the validation of a Chinese version of NPAD for use in China, which is culturally relevant, reliable, repeatable, and psychometrically sound.”
“Pavlakis M, Hanto DW. Clinical pathways in transplantation: a review and examples from Beth Israel Deaconess Medical Center. ?Clin Transplant 2011 DOI: 10.1111/j.1399-0012.2011.01564.x.(C) 2011 John Wiley & Sons A/S. Abstract: Clinical pathways (CP) have been developed to aid in the management of many surgical and medical conditions. Studies show the benefits of CP on outcomes including reduction in length of stay (LOS), morbidity, costs, and improvement in patient satisfaction (Arch Surg 2008: 394: 31; J Eval Clin Pract 2007: 13: 920; Arch Otolaryngol Head Neck Surg 2000: 126: 322; Circulation 2000: 101: 461; BMC Pulm Med 2006: 6: 22; Int J Health Care Qual Assur 2006: 19: 237; Am J Med Qual 2005: 20: 83; Am J Surg 2006: 192: 399; Am Surg 2005: 71: 152). Reports of CP in solid organ transplantation are lacking, possibly given the complexity of the transplant procedures that entail a complex, multidisciplinary pre-operative evaluation, inpatient, and post-operative time frames.

6, 3.0, and

5.1%, respectively; they were highly homogeneous, and a compact morphological structure was obtained. The extraction capacities of prometryn, tetracycline, and propranolol with corresponding MW-coated fibers were approximately 10.4, 3.9, and 3.3 times as much as those with the nonimprinted polymer (NIP)-coated fibers, respectively, and the selectivity factors of prometryn, tetracycline, and propranolol MIP coatings for the template molecules and structural analogues were 2.2-10.4, 2.2-3.9, and 1.3-3.3, respectively, in comparison with the corresponding NIP coatings. In comparison with commercial polydimethylsiloxane/divinylbenzene coatings that were approximately 3 times thicker, the extracted amounts of prometryn, tetracycline, and propranolol were 4.2, 12.3, and 7.7 times higher with prometryn, tetracycline, and propranolol JNJ-26481585 solubility dmso MIP coatings, respectively. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 1266-1277, 2011″
“Epilepsy has been associated with increased

risk of suicide; however, few studies have examined the relationship between epilepsy and suicidal behavior. The aims of this study were to evaluate the frequency of suicidal behavior in people with epilepsy and to identify characteristics that are associated with suicidal ideation in epilepsy. Of 171 people with epilepsy identified in a previous survey, 139 were included. A structured interview was conducted, and a second psychiatric evaluation was scheduled for Apoptosis inhibitor those who agreed. The frequencies of suicidal thoughts, plans, and attempts during lifetime were check details 36.7, 18.2, and 12.1%, respectively. The following conditions were strongly associated with suicidal thoughts; anxiety (OR = 3.3, 95% CI = 1.4-7.5, P = 0.001), depression (OR = 4.8, 95% Cl = 1.9-12.5, P = 0.001), and two or more standardized psychiatric diagnoses (OR = 21.6, 95% CI = 4.4-105.9, P < 0.0001). Although specific characteristics of epilepsy were found to be related to suicidal thoughts, psychiatric diseases also play an essential role. (C) 2010 Elsevier Inc. All rights reserved.”
“The binding

capacity of bile salts by lentil flours produced from two varieties, Blaze and Laird and their protein concentrates and hydrolysates were studied. Sodium cholate, sodium deoxycholate, sodium taurocholate, sodium glycocholate and sodium chenodeoxycholate were tested individually, and their binding interactions with the lentil products were analyzed using the Trinity Biotech Bile Acids Kit 450-10 and compared to cholestyramine. All tested samples bound the bile salts investigated, and the amount of bile salts bound (>70%) was sometimes greater than that bound by cholestyramine. Overall, there were no major differences in the bile salt binding capacities of similar samples prepared from the two varieties of lentil.

The mean age and known risk factors for PRAE (asthma, recent upper respiratory tract infection (<= 2 weeks), passive smoking, hayfever, past or present eczema, nocturnal dry cough) were similar among the groups. The proportion of patients with desaturation (< 95%) between induction of anesthesia and discharge from the recovery room was higher in the two groups who received TAL (data combined for all patients receiving lidocaine regardless of administration method, P = 0.01) compared to those who received no TAL. No difference in the rates of laryngospasm (P = 0.13) or cough (P = 0.07) was observed among the groups. There was no difference

in the rates of PRAE between the groups given TAL directly onto the vocal cords and in those whom received TAL blindly.

Conclusions:

Selleckchem Elafibranor The incidence of desaturation was higher in patients receiving TAL compared with children who did not. This association should Ubiquitin inhibitor perhaps be considered when contemplating the use of this technique.”
“Thin films grown by Al2O3 atomic layer deposition (ALD) and SiN plasma-enhanced chemical vapor deposition (PECVD) have been tested as gas diffusion barriers either individually or as bilayers on polymer substrates. Single films of Al2O3 ALD with thicknesses of >= 10 nm had a water vapor transmission rate (WVTR) of <= 5 x 10(-5) g/m(2) day at 38 degrees C/85% relative humidity (RH), as measured by the Ca test. This WVTR value was limited by H2O permeability through the epoxy seal, as determined by the Ca test for the glass lid control. In comparison, SiN PECVD films with a thickness of 100 nm had a WVTR of similar to 7 x 10(-3) g/m(2) day at JQ1 38 degrees C/85% RH. Significant improvements resulted when the SiN PECVD film was coated with an Al2O3 ALD film. An Al2O3

ALD film with a thickness of only 5 nm on a SiN PECVD film with a thickness of 100 nm reduced the WVTR from similar to 7 x 10(-3) to <= 5 x 10(-5) g/m(2) day at 38 degrees C/85% RH. The reduction in the permeability for Al2O3 ALD on the SiN PECVD films was attributed to either Al2O3 ALD sealing defects in the SiN PECVD film or improved nucleation of Al2O3 ALD on SiN. (C) 2009 American Institute of Physics. [DOI:10.1063/1.3159639]“
“Background: In adults, placement of the laryngeal mask airway causes increased overlapping of the internal jugular vein (IJV) and common carotid artery (CCA). However, few studies in children have been reported. The aim of this study was to describe the degree of overlap of the IJV and the CCA before and after laryngeal mask airway placement in infants and children.

Method: There were 160 children scheduled to undergo Protex (R) SoftSeal (R) and Ambu (R) placement. Patients were initially positioned in the 15 degrees Trendelenburg position with their heads rotated 30 degrees to the left.

In the uncontrolled pilot study, we observed improved brachial artery flow-mediated dilation

(7.7 +/- 2.9% to 8.7 +/- 3.1%, P = 0.01) and digital pulse amplitude tonometry ratio (0.10 +/- 0.12 Selleck GSK1838705A to 0.23 +/- 0.16, P = 0.001) 4 h after consumption of a single 480-mL portion of cranberry juice.

Conclusions: Chronic cranberry juice consumption reduced carotid femoral pulse wave velocity-a clinically relevant measure of arterial stiffness. The uncontrolled pilot study suggested an acute benefit; however, no chronic effect on measures of endothelial vasodilator function was found. This trial was registered at clinicaltrials.gov as NCT00553904. Am J Clin Nutr 2011;93:934-40.”
“Purpose: To describe a successful clinical case of immediate prosthetic loading of modified sandblasting and acid-etching surface ITI dental implants inserted in

a grafted maxilla after ATM Kinase Inhibitor Le Fort I osteotomy.

Materials and Methods: A 59-year-old man with a severely atrophied maxilla was treated with Le Fort I osteotomy and interpositional iliac bone graft. Thirteen weeks later, 7 modified sandblasted and acid-etched surface ITI dental implants were inserted with immediate application of a screw-fixed prosthetic acrylic device kept in functional loading for 3 months until a definitive fixed prosthesis was inserted.

Results: After 20-month follow-Lip there has been no implant failure, with minimal bone loss and healthy peri-implant soft tissues; the patient is functionally and esthetically satisfied.

Conclusions: Immediate loading of implants placed after Le Fort I osteotomy and interpositional iliac bone grafting could be an applicable protocol to rehabilitate extremely atrophied CBL0137 ic50 edentulous maxillas. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surgeons 67:1486-1494, 2009″
“Background: This study applied item response theory (IRT) and latent class analysis (LCA) procedures to examine the dimensionality and heterogeneity

of comorbid substance use disorders (SUDs) and explored their utility for standard clinical assessments, including the Addiction Severity Index (ASI), HIV Risk Behavior Scale (HRBS), and SF-36 quality-of-life measures.

Methods: The sample included 343 opioid-dependent patients enrolled in two national multisite studies of the U.S. National Drug Abuse Treatment Clinical Trials Network (CTN001-002). Patients were recruited from inpatient and outpatient addiction treatment settings at 12 programs. Data were analyzed by factor analysis, IRT, LCA, and latent regression procedures.

Results: A two-class LCA model fit dichotomous SUD data empirically better than one-parameter and two-parameter IRT models.

1%%). Survival of our patients

was less than in developed countries and cardiac complications were the most common cause of mortality and morbidity in these patients. Regarding the key role of iron chelation in prevention of different complications in BTM, correction of iron chelation regimen should be well considered.</.”
“This study aimed Selleck Dibutyryl-cAMP to find out the primary factors influencing the diameter of electrospun nanofibers of nylon-6,6 using artificial neural networks (ANNs). Four variables, namely, polymer concentration, working distance, injection rate, and applied voltage were considered as input parameters and the nanofibers diameter measured by scanning electron microscopy was taken as the output. The data were modeled and validated against a set of unseen data. The generated model was used to study the interactions occurring between the

input variables and their effect on the diameter. Results show that the injection rate and the polymer concentration are major factors affecting the nanofibers diameter with inverse and direct relations with the diameter, respectively, while the working distance and the applied voltage have direct but minor effects on nanofibers diameter. (C) 2011 Wiley Periodicals, Inc. J Appl GSK1904529A in vitro Polym Sci, 2012″
“In this work, bubble polarization domains in periodically ordered ferroelectric Pb(Zr(0.4)Ti(0.6))O(3) nanodot arrays and their formation mechanisms have been investigated by piezoresponse force microscopy (PFM) and Monte-Carlo simulations. The PFM observations reveal the coexistence of single domain and apparent bubble domain patterns within the same nanodot array, which also exhibit dissimilar polarization reversal processes. The formation of various polarization configurations can be accounted for by the interplay of various factors, such as polarization anisotropy and depolarization field. Using Monte-Carlo simulation, we are able to reproduce bubble and single domains and further predict that these patterns can be tailored by varying the

nanodot parameters, including dot height, aspect ratio, etc. (C) 2011 American Institute of Physics. [doi:10.1063/1.3623766]“
“Background: The increased frequency of laparoscopic learn more hepatic resection as a principal or adjunct component of patient care has driven the need for and development of efficient and safe hepatic parenchymal transection technologies. At present, various devices are available for pre-coagulation transection (PCT) of hepatic parenchyma with the intent of minimizing procedure-associated postoperative haemorrhage and bile leak. This report presents the evaluation of a novel bipolar radiofrequency (RF) energy device for PCT used for laparoscopic hepatic resection.

Methods: Patients undergoing laparoscopic hepatic resection using the Enseal (TM) device (SurgRx Inc.) were identified from the prospectively maintained hepatobiliary database.